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Table 1 Effect of ( S )-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate (TeAsp) on the activity of the antioxidant enzymes Catalase, Glutathione Peroxidase (GPx) and Glutathione Reductase (GR) from adult mice brain and liver

From: Sub-acute administration of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate induces toxicity and oxidative stress in mice: unexpected effects of N-acetylcysteine

Treatment

Catalase activitya

GPx activityb

GR activityb

 

Brain

Liver

Brain

Liver

Brain

Liver

PBS/DMSO

0.55 ± 0.04

4.44 ± 0.7

8.12 ± 0.6

93.0 ± 3.6

21.05 ± 0.1

38.6 ± 4.3

NAC/DMSO

0.66 ± 0.1

5.19 ± 0.8

9.09 ± 0.6

105.1 ± 9.2

25.58 ± 2.55

45.6 ± 3.9

PBS/TeAsp

0.57 ± 0.05

3.72 ± 0.5

8.47 ± 0.4

91.8 ± 2.5

18.94 ± 0.65

44.8 ± 5.1

NAC/TeAsp

0.64 ± 0.1

3.38 ± 0.32

7.06 ± 0.65

97.1 ± 7.2

19.862.0

62.5 ± 5.9*

  1. Results are mean ± S.E.M., n= 5 per group. One way ANOVA followed by Newman-Keuls Multiple Comparison Test.
  2. *Values significantly different from the PBS/DMSO group with p<0.05.
  3. aCatalase activity is expressed as μmol H2O2/min/mg of protein.
  4. bGPx activity and GR activity are expressed as nmol NADPH/min/mg of protein.