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Table 1 Effect of ( S )-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate (TeAsp) on the activity of the antioxidant enzymes Catalase, Glutathione Peroxidase (GPx) and Glutathione Reductase (GR) from adult mice brain and liver

From: Sub-acute administration of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate induces toxicity and oxidative stress in mice: unexpected effects of N-acetylcysteine

Treatment Catalase activitya GPx activityb GR activityb
  Brain Liver Brain Liver Brain Liver
PBS/DMSO 0.55 ± 0.04 4.44 ± 0.7 8.12 ± 0.6 93.0 ± 3.6 21.05 ± 0.1 38.6 ± 4.3
NAC/DMSO 0.66 ± 0.1 5.19 ± 0.8 9.09 ± 0.6 105.1 ± 9.2 25.58 ± 2.55 45.6 ± 3.9
PBS/TeAsp 0.57 ± 0.05 3.72 ± 0.5 8.47 ± 0.4 91.8 ± 2.5 18.94 ± 0.65 44.8 ± 5.1
NAC/TeAsp 0.64 ± 0.1 3.38 ± 0.32 7.06 ± 0.65 97.1 ± 7.2 19.862.0 62.5 ± 5.9*
  1. Results are mean ± S.E.M., n= 5 per group. One way ANOVA followed by Newman-Keuls Multiple Comparison Test.
  2. *Values significantly different from the PBS/DMSO group with p<0.05.
  3. aCatalase activity is expressed as μmol H2O2/min/mg of protein.
  4. bGPx activity and GR activity are expressed as nmol NADPH/min/mg of protein.
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