Table 2 Type of interactions and interacting amino acid residues of COX-2 protein with selected ligands
From: In –silico molecular docking analysis of prodigiosin and cycloprodigiosin as COX-2 inhibitors
COX-2 Protein | H-Bonding | V-waal | Pi-pi | Pi-sigma | Pi-cation |
|---|---|---|---|---|---|
Cycloprodigiosin | Tyr324 | ----- | Phe487 | ----- | Arg89 |
Prodigiosin | Leu321, Tyr324 | ----- | ----- | ----- | ----- |
Rofecoxib | ----- | ----- | ----- | ----- | Arg89 |
Celecoxib | His58, tyr324, gln161, leu321 | ----- | ----- | ----- | Arg89 |