Table 2 Downregulated pathway
From: Gene expression profiling of the anti-glioma effect of Cilengitide
Pathway name | Entrez gene ID | Gene symbol | P-value | Z score |
|---|---|---|---|---|
Sphingolipid metabolism | 8879 | SGPL1 | 0.006 | 16.049 |
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 598 | BCL2L1 | 0.015 | 8.496 |
G alpha (s) signalling events | 134860, 4160 | TAAR9, MC4R | 0.022 | 3.717 |
Syndecan-3-mediated signaling events | 4160 | MC4R | 0.032 | 5.52 |
Sphingosine 1-phosphate (S1P) pathway | 8879 | SGPL1 | 0.038 | 5.036 |
Signaling events mediated by the Hedgehog family | 91653 | BOC | 0.042 | 4.771 |
Pentose phosphate pathway | 8277 | TKTL1 | 0.045 | 4.54 |