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Table 2 Downregulated pathway

From: Gene expression profiling of the anti-glioma effect of Cilengitide

Pathway name Entrez gene ID Gene symbol P-value Z score
Sphingolipid metabolism 8879 SGPL1 0.006 16.049
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 598 BCL2L1 0.015 8.496
G alpha (s) signalling events 134860, 4160 TAAR9, MC4R 0.022 3.717
Syndecan-3-mediated signaling events 4160 MC4R 0.032 5.52
Sphingosine 1-phosphate (S1P) pathway 8879 SGPL1 0.038 5.036
Signaling events mediated by the Hedgehog family 91653 BOC 0.042 4.771
Pentose phosphate pathway 8277 TKTL1 0.045 4.54