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Table 1 Significantly enriched pathways between cilengitide-treated U87ΔEGFR and control

From: Gene expression profiling of the anti-glioma effect of Cilengitide

Pathwayname Entrez gene ID Gene symbol P-value Z score
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 23586, 841 DDX58, CASP8 0.004 6.358
Organic cation/anion/zwitterion transport 55867, 6580 SLC22A11, SLC22A1 0.005 6.084
Cell adhesion molecules (CAMs) 1364, 4359, 941, :965 CLDN4, MPZ, CD80, CD58 0.014 3.213
NOSIP mediated eNOS trafficking 4846 NOS3 0.022 8.034
EPHB forward signaling 8867, 8997 SYNJ1, KALRN 0.026 3.585
Apoptotic cleavage of cellular proteins 1832, 841 DSP, CASP8 0.034 3.262
Regulation of RAC1 activity 2059, 8997 EPS8, KALRN 0.036 3.204
Activation, myristolyation of BID and translocation to mitochondria 841 CASP8 0.037 5.593
Fatty acids 1580 CYP4B1 0.037 2.177
Signaling in Immune system 23586, 3429, 6196, 6672, :841, 84433, 941 DDX58, IFI27, RPS6KA2, SP100, CASP8, CARD11, CD80 0.037 3.149
LKB1 signaling events 2011, 57521 MARK2,RPTOR 0.037 2.631
ErbB1 downstream signaling 2059, 4086, 5590 EPS8, SMAD1, PRKCZ 0.039 4.964
FasL/CD95L signaling 841 CASP8 0.044 4.964
NOSTRIN mediated eNOS trafficking 4846 NOS3 0.044 4.964
Organic anion transport 55867 SLC22A11, 0.044 4.964
Pyrimidine biosynthesis 7372 UMPS 0.044 4.964
Release of eIF4E 57521 PRTOR 0.044 4.964
Ceramide signaling pathway 5590, 841 PRKCZ, CASP8 0.046 2.899
TNF receptor signaling pathway 5590, 841 PRKCZ, CASP8 0.046 2.899
Thromboxane A2 receptor signaling 4846, 5590 NOS3, PRKCZ 0.048 2.853