Table 1 Significantly enriched pathways between cilengitide-treated U87ΔEGFR and control

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

23586, 841

DDX58, CASP8

0.004

6.358

Organic cation/anion/zwitterion transport

55867, 6580

SLC22A11, SLC22A1

0.005

6.084

Cell adhesion molecules (CAMs)

1364, 4359, 941, :965

CLDN4, MPZ, CD80, CD58

0.014

3.213

NOSIP mediated eNOS trafficking

4846

NOS3

0.022

8.034

EPHB forward signaling

8867, 8997

SYNJ1, KALRN

0.026

3.585

Apoptotic cleavage of cellular proteins

1832, 841

DSP, CASP8

0.034

3.262

Regulation of RAC1 activity

2059, 8997

EPS8, KALRN

0.036

3.204

Activation, myristolyation of BID and translocation to mitochondria

841

CASP8

0.037

5.593

Fatty acids

1580

CYP4B1

0.037

2.177

Signaling in Immune system

23586, 3429, 6196, 6672, :841, 84433, 941

DDX58, IFI27, RPS6KA2, SP100, CASP8, CARD11, CD80

0.037

3.149

LKB1 signaling events

2011, 57521

MARK2,RPTOR

0.037

2.631

ErbB1 downstream signaling

2059, 4086, 5590

EPS8, SMAD1, PRKCZ

0.039

4.964

FasL/CD95L signaling

841

CASP8

0.044

4.964

NOSTRIN mediated eNOS trafficking

4846

NOS3

0.044

4.964

Organic anion transport

55867

SLC22A11,

0.044

4.964

Pyrimidine biosynthesis

7372

UMPS

0.044

4.964

Release of eIF4E

57521

PRTOR

0.044

4.964

Ceramide signaling pathway

5590, 841

PRKCZ, CASP8

0.046

2.899

TNF receptor signaling pathway

5590, 841

PRKCZ, CASP8

0.046

2.899

Thromboxane A2 receptor signaling

4846, 5590

NOS3, PRKCZ

0.048

2.853