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Table 3 Changes in string initial rundown rates of endplate potentials (EPPs) before and after treatment of the isolated rat phrenic nerve diaphragm preparation with rocuronium or vecuronium

From: Effects of rocuronium and vecuronium on initial rundown of endplate potentials in the isolated phrenic nerve diaphragm preparation of rats

Drug (μg/ml) Before treatment 3 min after treatment 5 min after treatment
M1 MX R (%) M1 MX R (%) M1 MX R (%)
Rocuronium 2.5 46 ± 11 34 ± 10 26 46 ± 10 28 ± 10 40* 45 ± 12 26 ± 10* 42*
Vecuronium 0.5 46 ± 11 33 ± 11 28 46 ± 11 31 ± 10 33 45 ± 12 29 ± 11* 37*
  1. * P < 0.05, compared with the corresponding group without drug treatment; n = 5. M1, the first quantum content of EPP; MX, the 11 to 55 average quantum content of EPP; R, the rundown rate. M = Vc/q; Vc is the corrected amplitude of EPP and q is the quantum size of the MEPP. Data shown are means ± SEM.