Effects of rocuronium and vecuronium on initial rundown of endplate potentials in the isolated phrenic nerve diaphragm preparation of rats

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Table 2 Effects of vecuronium on the amplitude of endplate potentials (EPPs) in the isolated rat phrenic nerve diaphragm preparation at different time points after treatment

Vecuronium (μg/ml)	EPP (mV) before administration	EPP (mV) at different times after treatment
Vecuronium (μg/ml)	EPP (mV) before administration	3 min	5 min	10 min
Control	32.4 ± 3.3	32.2 ± 3.3	31.4 ± 3.2	31.2 ± 2.9
0.5	32.3 ± 3.4	31.7 ± 2.9	30.6 ± 3.3	29.7 ± 2.2
1.0	31.5 ± 3.2	27.4 ± 2.7	22.4 ± 2.8^*	16.4 ± 2.1^**##
2.0	33.1 ± 3.4	22.4 ± 3.3^*#	14.4 ± 1.4^**##	12.4 ± 1.3^**##
4.0	32.7 ± 3.1	18.4 ± 3.3^**##	12.4 ± 1.5^**##	8.4 ± 1.3^**##

^* P < 0.05, ^** P < 0.01, compared with the corresponding group without vecuronium; ^# P < 0.05, ^## P < 0.01, compared with the control at the same time point; n = 5. Data shown are means ± SEM.