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Table 2 Effects of vecuronium on the amplitude of endplate potentials (EPPs) in the isolated rat phrenic nerve diaphragm preparation at different time points after treatment

From: Effects of rocuronium and vecuronium on initial rundown of endplate potentials in the isolated phrenic nerve diaphragm preparation of rats

Vecuronium (μg/ml) EPP (mV) before administration EPP (mV) at different times after treatment
3 min 5 min 10 min
Control 32.4 ± 3.3 32.2 ± 3.3 31.4 ± 3.2 31.2 ± 2.9
0.5 32.3 ± 3.4 31.7 ± 2.9 30.6 ± 3.3 29.7 ± 2.2
1.0 31.5 ± 3.2 27.4 ± 2.7 22.4 ± 2.8* 16.4 ± 2.1**##
2.0 33.1 ± 3.4 22.4 ± 3.3*# 14.4 ± 1.4**## 12.4 ± 1.3**##
4.0 32.7 ± 3.1 18.4 ± 3.3**## 12.4 ± 1.5**## 8.4 ± 1.3**##
  1. * P < 0.05, ** P < 0.01, compared with the corresponding group without vecuronium; # P < 0.05, ## P < 0.01, compared with the control at the same time point; n = 5. Data shown are means ± SEM.