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Figure 1

From: Effects of rocuronium and vecuronium on initial rundown of endplate potentials in the isolated phrenic nerve diaphragm preparation of rats

Figure 1

Effects of rocuronium and vecuronium on the rundown rate of trains of endplate potentials (EPPs) in the isolated phrenic nerve diaphragm preparation of rats. (A) Examples of the single normal EPP (a) and trains of EPPs (b) in the isolated phrenic nerve diaphragm preparation. The second wave of the normal EPP was higher than the first wave (a). In the trains of EPPs (b), the amplitude of EPP1 was 32.4 mV; the average amplitude of EPP11-50 was 27.8 mV; the decay rate (R) = [1−(EPP11-50 average quantum content/EPP1 quantum content)] × 100% = 74%. n = 2 (a) or 50 (b). (B) The effect of rocuronium (2.5 μg/ml) on the rundown rate of trains of EPPs at 3 min after drug administration. (a) Normal control; (b) post-treatment of rocuronium. (C) The effect of vecuronium (0.5 μg/ml) on the rundown rate of trains of EPPs at 5 min after drug administration. (a) Normal control; (b) post-treatment of vecuronium.

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