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Table 3 Cox-regression multivariate analysis of predictive factors for time to brain metastases (TTBM) from initial distant metastases

From: Clinical implication of Time To Brain Metastasis (TTBM) according to breast cancer subtypes

Characteristics HR (95% C.I.) P-value
Age at first diagnosis of primary disease 1.001 (0.985-1.018) 0.863
Stage IV at initial diagnosis of primary BC 0.843 (0.475-1.495) 0.559
Site of initial distant metastases   
 Bone 0.695 (0.498-0.969) 0.033
 Lung 1.138 (0.811-1.597) 0.453
 Liver 1.431 (0.934-2.190) 0.099
Subtype with trastuzumab effect   
 HR-positive/HER2-negative reference  
 HER2-positive withoutTrastuzumab 1.892 (1.177-3.040) 0.008
 HER2-positive with Trastuzumab 1.064 (0.650-1.741) 0.656
 TNBC 1.652 (1.071-2.546) 0.023