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Table 3 Example of integrin triplets of marine sponges in the protomers of human receptor heteromers and in subunits of the neuromuscular nicotinic receptor

From: Integrin triplets of marine sponges in the murine and human MHCI-CD8 interface and in the interface of human neural receptor heteromers and subunits

Receptor heteromer Reference Function LLG GLL ITL RPA DGR
MHCI-CD8a Gao et al. (1997) Adaptive immune response - - # + -
Wang et al. (2009)
MHC1-CD8b Wang et al. (2009) Adaptive immune response - - # - -
CD8a-CD8b Wang et al. (2009) Coreceptor of T cells - - + - -
ITGAIIB-ITGB3 Barczyk et al. (2010) RGD (Arg-Gly-Asp) receptor - # - - #
ITGAV-ITGB3 Barczyk et al. (2010) RGD receptor - # - - -
ITGAV-ITGB5 Barczyk et al. (2010) RGD receptor # - - - -
ITGAV-ITGB6 Barczyk et al. (2010) RGD receptor - # - - -
ITGAV-ITGB8 Barczyk et al. (2010) RGD receptor - # - - -
ITGAL-ITGB2 Barczyk et al. (2010) Leukocyte receptor - + - - -
ITGAM-ITGB2 Barczyk et al. (2010) Leukocyte receptor - + - - -
ITGAX-ITGB2 Barczyk et al. (2010) Leukocyte receptor - + - - -
GABAB1-GABAB2 Marshall et al. (2001) Activation of the potassium channels and regulation of receptor trafficking - # # - -
GABAB1-mGluR1 Hirono et al. (2001) Modulation of excitatory transmission - # + - -
GABAB1-CXCR4 Guyon and Nahon (2007) Modulation of neuroendocrine systems - - # - -
ACHA-ACHB Changeux et al. 1984 Part of the neuromuscular nicotinic receptor + - - - -
ACHA-ACHE Changeux et al. 1984 Part of the neuromuscular nicotinic receptor + - - - -
ACHB-ACHD Changeux et al. 1984 Part of the neuromuscular nicotinic receptor - - + # -
  1. (+ yes in both receptors, # may mediate their interaction, - no in any receptor).