Table 3 Example of integrin triplets of marine sponges in the protomers of human receptor heteromers and in subunits of the neuromuscular nicotinic receptor

MHCI-CD8a

Gao et al. (1997)

Adaptive immune response

-

-

#

+

-

Wang et al. (2009)

MHC1-CD8b

Wang et al. (2009)

Adaptive immune response

-

-

#

-

-

CD8a-CD8b

Wang et al. (2009)

Coreceptor of T cells

-

-

+

-

-

ITGAIIB-ITGB3

Barczyk et al. (2010)

RGD (Arg-Gly-Asp) receptor

-

#

-

-

#

ITGAV-ITGB3

Barczyk et al. (2010)

RGD receptor

-

#

-

-

-

ITGAV-ITGB5

Barczyk et al. (2010)

RGD receptor

#

-

-

-

-

ITGAV-ITGB6

Barczyk et al. (2010)

RGD receptor

-

#

-

-

-

ITGAV-ITGB8

Barczyk et al. (2010)

RGD receptor

-

#

-

-

-

ITGAL-ITGB2

Barczyk et al. (2010)

Leukocyte receptor

-

+

-

-

-

ITGAM-ITGB2

Barczyk et al. (2010)

Leukocyte receptor

-

+

-

-

-

ITGAX-ITGB2

Barczyk et al. (2010)

Leukocyte receptor

-

+

-

-

-

GABAB1-GABAB2

Marshall et al. (2001)

Activation of the potassium channels and regulation of receptor trafficking

-

#

#

-

-

GABAB1-mGluR1

Hirono et al. (2001)

Modulation of excitatory transmission

-

#

+

-

-

GABAB1-CXCR4

Guyon and Nahon (2007)

Modulation of neuroendocrine systems

-

-

#

-

-

ACHA-ACHB

Changeux et al. 1984

Part of the neuromuscular nicotinic receptor

+

-

-

-

-

ACHA-ACHE

Changeux et al. 1984

Part of the neuromuscular nicotinic receptor

+

-

-

-

-

ACHB-ACHD

Changeux et al. 1984

Part of the neuromuscular nicotinic receptor

-

-

+

#

-