Scheme 3From: Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the Excitatory Amino Acid Transporters (EAATs): improving the potency of a micromolar screening Hit is not truism Synthesis of piperazine analogs 3.1, 3.5, 3.8-3.11 by use of the coupling reagent TBTU a . a Reagents and conditions: (a) TBTU, DIPEA, dry DMF, rt, 20 h, 40-58%.Back to article page