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Scheme 2

From: Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the Excitatory Amino Acid Transporters (EAATs): improving the potency of a micromolar screening Hit is not truism

Scheme 2

Synthesis of piperazine analog (±)- endo-exo -3.2 a . a Reagents and conditions: (a) KMnO4, K2CO3, H2O, rt, 17 h. (b) Piperazine, DIPEA, TBTU, DMF, rt, 24 h, 49%. (c) 1-Bromo-4-(trifluoromethyl)benzene, Pd(OAc)2, P(tBu)3, NaOtBu, dry o-xylene, 120°C, 24 h, 56%.

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