Seventeen years after BRCA1: what is the BRCA mutation status of the breast cancer patients in Africa? – a systematic review

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Table 2 Exon(s)/mutations evaluated

STUDY	BRCA1	BRCA2
Yawitch	185delAG in exon 2, 4184del4, 943ins10 and 1832deI5 in exon 11, and 5382insC in exon 20, and Met1775Arg in exon 21	NONE
Gao	ALL	ALL
Fackenthal	ALL	ALL
Zhang B	Y101X (422 T[G), exon 7	NONE
Masri	NONE	Exon 11
Awadelkarim	ALL	ALL
Zhang J	ALL	NONE
Stoppa Lyonnet	??	??
Van der Merwe	185delAG, 5382insC, 1493delC, 2760 G > T, Exon 10	Exon 10 & 11 , 6174delT, 8162delG
	NORTH AFRICA
Balci
Ozdag et al. (2000)	2, 5,11 (10 overlapping fragments), 13, 20, 24	11 (7 overlapping fragments)
Yazici	2, 11, 14, 20 (ALL in a subset of patients)	10, 11
Uhrhammer et al. (2008)	ALL	NONE
Troudi et al. (2007)	ALL	ALL
Cherbal F (2010)	ALL	ALL
Mahfoudh et al. (2011)	ALL