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Figure 4

From: Complement anaphylatoxins C3a and C5a induce a failing regenerative program in cardiac resident cells. Evidence of a role for cardiac resident stem cells other than cardiomyocyte renewal

Figure 4

C3a/C5a induce proliferation and migration in CPCs. A) CPCs treated with C3a and C5a showed an increase in DNA 3H-thymidine incorporation with respect to the control. B) CPCs migrated towards C3a and C5a gradients when migration was assessed in a Boiden chamber assay. The optimal doses for both proliferation and migration are C3a = 50 nM and C5a = 15 nM. Data were normalized versus control. p ≤ 0.05 (*); p ≤ 0.01 (**).

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