Figure 4

Histopathology of group 3. Figures 4A and B are from case M10-1. Figures 4C and D are from case M10-2. In M10-1, severe destructive inflammation and development of granulation tissue, and tissue detached by coagulation necrosis (cn) were observed with ulcer formation (Figure 4A). Cellular infiltration was observed mainly in the laminapropria mucosa (lm) and sub-mucosa (sm) but was not severe in the muscular layer (ml) (Figure 4A).Other areas of the colon exhibited erosion (er), edema (e), mild cellular infiltration, and irregular crypt (ic) structures (Figure 4B). Case M10-2 exhibited a small ulcer (ul), erosion (er), cellular infiltration, and irregular crypt (ic); however, no severe necrotizing lesions were apparent.