Skip to main content
Figure 3 | SpringerPlus

Figure 3

From: Mycobacterium avium subsp. paratuberculosis lipophilic antigen causes Crohn’s disease-type necrotizing colitis in Mice

Figure 3

Histopathology of group 2. Figures 3A-F are from case M100-2. Figures 3G and H are from case M100-3. All sections were stained with hematoxylin and eosin (H&E), and the magnification is denoted by a bar. Case M100-2 exhibited severe full-thickness destructive enteritis (Figures 3A-F). The most severe change was deep ulceration and necrotizing enteritis (ne) (Figures 3A and B). Accumulation of inflammatory cells (aic) and debris, and edema (e) are seen as a pseudomembrane (Figures 3A and B). The normal structure of the mucosa completely disappeared (arrows); however, the severity differed from area to area in the same case. The structure of the epithelium was maintained in some areas of the colon, but infiltration and edema were observed in the muscle layer (ml) (Figures 3C and D). Cellular infiltration was observed between circular muscular fibers (Figure 3E). Edema and cellular infiltration of the longitudinal muscle (lm) and serosal membrane occurred (Figure 3F). Fibrin deposition (f) was observed on the serosal membrane (sm) (Figure 3F). Full-thickness necrotizing enteritis is seen in case M100-3 (Figure 3G). Pseudomembrane (pm) is observed (Figure 3F). Infiltration in the muscle layer is significant (Figure 3G). Cellular infiltration and granulation tissue are observed where ulcers (ul) form (Figure 3H).

Back to article page