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Figure 1 | SpringerPlus

Figure 1

From: Mycobacterium avium subsp. paratuberculosis lipophilic antigen causes Crohn’s disease-type necrotizing colitis in Mice

Figure 1

A. Histopathological data of experimental enteritis generated by TNBS and Mycobacterium avium subsp. paratuberculosis antigen in C57BL/6 mice. The longitudinal axis represents types of treatment and numbers of mice. C: Control injected with only vehicle. CL: Mice injected subcutaneously (SC) with vehicle and with MAP-L100 antigen via the intra-colon (IC) route. M1: Mice injected subcutaneously with MAP-l00 plus MAP-L1 via the IC route. M10: Mice injected subcutaneously with MAP-l00 and with MAP-L10 via the IC route. M100: Mice injected subcutaneously with MAP-l00 and with MAP-L100 via the IC route. T: Mice injected subcutaneously with 2.5% TNBS and with 10% via the IC route. Color bars indicate the type of lesion: Atypical epithelial cells (Atyp-ep), irregularly shaped crypt (Ir-Cryp), ulcer (Ulcer), erosion (Erosion), edema (Edema), and cellular infiltration (C-inf). The length of each color bar indicates the intensity (index 0 to 3). The total length of the color bar (horizontal axis) indicates the total degree of enteritis. B. Distribution of lesions in lamina propria mucosa (Mucosa), sub-mucosa, muscle layer (Muscle), serosa, and perforation. The degree of lesion (index 0 to 3) in each layer is denoted by the length of the bar. C. The type of inflammatory cell (neutrophil (N-if), macrophage (M-if), or lymphocyte (L-if)) is denoted by color, and the degree is denoted by the length of the bars.

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