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Table 1 Endocytosis related gene expression analysis in the MALME-3M cell line after treatment with albumin-associated lipids

From: Transdifferentiation of MALME-3M and MCF-7 Cells toward Adipocyte-like Cells is Dependent on Clathrin-mediated Endocytosis

GENE SYMBOL GENE DESCRIPTION ENSEMBL ID FOLD CHANGE
CLTC clathrin, heavy chain (Hc) ENSG00000141367 1.46
TFRC transferring receptor (p90, CD71) ENSG00000072274 3.33
AP1B1 adaptor-related protein complex 1, beta 1 subunit ENSG00000100280 1.62
AP1G1 adaptor-related protein complex 1, gamma 1 subumit ENSG00000166747 1.53
AP1S3 adaptor-related protein complex 1, sigma 3 subunit ENSG00000152056 2.29
AP2A1 adaptor-related protein complex 2, alpha 1 subunit ENSG00000196961 1.83
SYNRG synergin gamma or AP1 gamma subunit binding protein 1 ENSG00000006114 1.26
AP3M1 adaptor-related protein complex 3, mu 1 subunit ENSG00000185009 1.24
PICALM phosphatidylinositol binding clathrin assembly protein ENSG00000073921 1.20
CLINT1 clathrin interactor 1 ENSG00000113282 2.11
NECAP1 NACAP endocytosis associated 1 ENSG00000089818 1.36
IGF2R insulin-like growth factor 2 receptor ENSG00000197081 2.19
M6PR mannose-6-phosphate receptor (cation dependent) ENSG00000003056 1.42
PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide ENSG00000133056 1.79
EEA1 early endosome antigen 1 ENSG00000102189 1.91
LDLR low density lipoprotein receptor ENSG00000130164 2.01
LRP1 low-density lipoprotein receptor-related protein ENSG00000123384 1.70
LDLRAP1 low density lipoprotein receptor adaptor protein ENSG00000157978 1.29
ID NAME ADJ p VALUE
GO:0016197 endosome transport 1.06E-03
GO:0005905 coated pit 1.10E-03
GO:0030139 endocytic vesicle 1.10E-03
GO:0030131 clathrin adaptor complex 1.25E-03
GO:0030136 clathrin-coated vesicle 1.25E-03
GO:0030133 transport vesicle 1.69E-02
GO:0030135 coated vessicle 1.69E-02
GO:0030118 clathrin coat 2.09E-02
GO:0065002 intracellular protein transmembrane transport 2.12E-03
GO:0042325 regulation of phosphorylation 2.28E-03
GO:0006897 endocytosis 2.38E-02
GO:0030666 endocytic vesicle membrane 3.10E-03
GO:0045121 membrane raft 3.39E-02
GO:0005768 endosome 3.52E-03
GO:0032799 low-density lipoprotein receptor metabolic process 3.62E-03
GO:0001726 ruffle 5.84E-01
GO:0030117 membrane coat 5.84E-01
  1. (A) Fold-changes in endocytosis annotated genes. Fold changes were calculated after correcting the number of RNA-seq reads mapped to the gene in each condition by the total number of reads from the sequencing experiment for that condition. (B) Enrichment analysis of GO functional categories related to endocytosis. Adjusted p-values were obtained after Benjamini and Hochberg correction (Benjamini &[Hochberg 1995]). Significant categories (adjusted p-value <0.05) are indicated in bold.