Differential impact of body mass index and its change on the risk of breast cancer by molecular subtype: A case-control study in Japanese women

Sueta, Aiko; Ito, Hidemi; Islam, Tania; Hosono, Satoyo; Watanabe, Miki; Hirose, Kaoru; Fujita, Takashi; Yatabe, Yasushi; Iwata, Hiroji; Tajima, Kazuo; Tanaka, Hideo; Iwase, Hirotaka; Matsuo, Keitaro

doi:10.1186/2193-1801-1-39

Table 3 Associations between BMI and breast cancer risk by tumor subtype and menopausal status

From: Differential impact of body mass index and its change on the risk of breast cancer by molecular subtype: A case-control study in Japanese women

	Luminal (n=455)						Luminal / HER2 (n=108)						HER2 (n=84)						Triple negative (n=68)
	Premenopausal			Postmenopausal			Premenopausal			Postmenopausal			Premenopausal			Postmenopausal			Premenopausal			Postmenopausal
	Case			Case			Case			Case			Case			Case			Case			Case
	(n=236)	ORs	95% CI	(n=218)	ORs	95% CI	(n=56)	ORs	95% CI	(n=52)	ORs	95% CI	(n=29)	ORs	95% CI	(n=55)	ORs	95% CI	(n=19)	ORs	95% CI	(n=48)	ORs	95% CI
Current BMI (kg / m²)
< 18.5	30	1.23	0.70 - 2.15	9	0.65	0.28 - 1.50	5	0.63	0.16 - 2.56	2	0.66	0.09 - 4.83	3	0.48	0.04 - 5.64	4	0.34	0.06 - 1.82	3	-		2	0.43	0.04 - 4.12
18.5 - 21.9	123	1.00	(ref.)	61	1.00	(ref.)	31	1.00	(ref.)	23	1.00	(ref.)	10	1.00	(ref.)	22	1.00	(ref.)	11	1.00	(ref.)	12	1.00	(ref.)
22–24.9	51	0.92	0.59 - 1.45	76	1.46	0.94 - 2.29	17	1.95	0.64 - 5.99	13	0.81	0.27 - 2.42	12	3.67	0.69 - 19.5	18	0.80	0.26 - 2.47	4	-		18	2.74	0.81 - 9.22
≥ 25	28	0.96	0.55 - 1.68	71	2.13	1.33 - 3.42	3	0.17	0.03 - 1.03	14	2.38	0.75 - 7.58	4	2.66	0.13 - 52.8	11	1.04	0.33 - 3.30	1	-		16	7.51	1.84 - 9.22
Unknown	4			1			0			0			0			0			0			0
per1 kg / m² increase		0.97	0.92 - 1.03		1.14	1.07 - 1.20		0.96	0.81 - 1.13		1.14	0.99 - 1.30		1.18	0.91 - 1.53		1.05	0.93 - 1.18		-			1.21	1.05 - 1.39
Ptrend			0.363			<0.001			0.620			0.071			0.222			0.452						0.008
BMI at age 20 years
< 18.5	45	0.72	0.46 - 1.11	29	0.81	0.48 - 1.36	10	0.36	0.12 - 1.10	7	0.53	0.17 - 1.65	11	4.32	0.63 - 29.7	8	0.75	0.22 - 2.55	6	-		3	0.57	0.13 - 2.50
18.5 - 21.9	154	1.00	(ref.)	127	1.00	(ref.)	41	1.00	(ref.)	34	1.00	(ref.)	15	1.00	(ref.)	35	1.00	(ref.)	11	1.00	(ref.)	34	1.00	(ref.)
22 - 24.9	33	0.98	0.58 - 1.64	51	0.98	0.63 - 1.51	2	0.08	0.01 -0.56	9	1.71	0.40 - 7.37	3	20.9	1.03 - 421.7	9	2.23	0.63 - 7.91	1	-		8	0.79	0.26 - 2.35
≥ 25	2	0.40	0.07 - 2.16	6	0.97	0.32 - 3.00	2	0.58	0.01 - 23.7	2	1.10	0.07 - 17.5	0	-		2	2.99	0.17 - 53.9	1	-		2	0.54	0.06 - 4.96
Unknown	2			5			1			0			0			1			0			1
per1 kg / m² increase		1.06	0.97 - 1.15		1.02	0.94 - 1.11		0.98	0.79 - 1.23		1.13	0.89 - 1.42		1.04	0.90 - 2.04		1.13	0.91 - 1.41		-				0.98
Ptrend			0.235			0.617			0.876			0.314			0.852			0.264						0.838
BMI change (from age 20 to the current age)
< −4	3	1.27	0.25 - 6.38	4	0.81	0.21 - 3.16	1	0.47	0.01 - 19.5	0	-		0	-		0	-		1	-		0	-
-4 to −2.1	14	1.18	0.56 - 2.48	8	0.71	0.30 - 1.70	2	1.09	0.14 - 8.64	0	-		0	-		4	0.74	0.06 - 8.53	0	-		2	0.62	0.08 - 4.87
−2 to +1.9	141	1.00	(ref.)	64	1.00	(ref.)	32	1.00	(ref.)	26	1.00	(ref)	15	1.00	(ref.)	27	1.00	(ref.)	11	1.00	(ref.)	18	1.00	(ref.)
+2 to +4.9	58	0.79	0.52 - 1.20	84	1.41	0.91 - 2.18	17	1.02	0.37 - 2.81	18	0.89	0.33 - 2.39	6	0.60	0.07 - 5.25	13	0.34	0.11 - 0.99	5	-		19	2.33	0.70 - 7.76
+5 to +7.9	9	0.55	0.22 - 1.38	34	1.90	1.05 - 3.41	3	1.05	0.17 - 6.54	5	0.44	0.10 - 1.91	6	12.1	0.75 - 195.9	8	0.85	0.21 - 3.36	2	-		5	3.13	0.45 - 21.7
≥ +8	6	0.98	0.33 - 2.96	18	5.50	2.14 - 14.1	0	-		3	5.66	0.31 - 102.3	2	-		2	2.40	0.17 - 33.3	0	-		3	4.41	0.31 - 61.9
Unknown	5			6			1			0			0			1			0			1
per1 kg / m² increase		0.93	0.87 - 1.00		1.16	1.09 - 1.23		0.96	0.80 - 1.16		1.10	0.95 - 1.27		1.35	0.94 - 1.95		1.00	0.88 - 1.14					1.18	1.02 - 1.36
Ptrend			0.054			<0.001			0.670			0.197			0.108			0.982						0.024

ORs were adjusted for age, age at menarche, menopause, parity, age at first live birth, family history of breast cancer, total exercise, hormone use, and referral pattern to our hospital.

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