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Table 2 Odds ratios (ORs) of breast cancer by the distribution of body mass index (BMI)

From: Differential impact of body mass index and its change on the risk of breast cancer by molecular subtype: A case-control study in Japanese women

  

All (n=2145)

 

Premenopausal (n=1020)

 

Postmenopausal (n=1119)

 
 

Case / Control

  

Case / Control

  

Case / Control

   
 

(n=715 / 1430)

ORs

95% CI

(n=340 / 680)

ORs

95% CI

(n=373 / 746)

ORs

95% CI

P interaction

Current BMI (kg / m2)

 

  < 18.5

59 / 150

0.93

0.66 - 1.33

41 / 83

1.11

0.70 - 1.76

17 / 67

0.66

0.36 - 1.23

 

  18.5 - 21.9

293 / 679

1.00

(ref.)

175 / 377

1.00

(ref.)

118 / 299

1.00

(ref.)

 

  22–24.9

210 / 379

1.26

0.99 - 1.59

84 / 144

1.08

0.75 - 1.55

125 / 234

1.38

0.99 - 1.93

 

  ≥ 25

148 / 210

1.61

0.99 - 1.59

36 / 74

0.88

0.55 - 1.41

112 / 136

1.98

1.39 - 2.82

 

  Unknown

5 / 12

  

4 / 2

  

1 / 10

   

  per1 kg / m2 increase

 

1.06

1.02 - 1.09

 

0.98

0.93 - 1.03

 

1.11

1.06 - 1.15

 

  Ptrend

  

< 0.001

  

0.373

  

< 0.001

0

BMI at age 20 years

 

  < 18.5

120 / 295

0.79

0.61 - 1.01

72 / 174

0.81

0.57 - 1.14

47 / 119

0.74

0.50 - 1.09

 

  18.5 - 21.9

452 / 842

1.00

(ref.)

221 / 412

1.00

(ref.)

230 / 429

1.00

(ref.)

 

  22–24.9

116 / 229

0.91

0.70 - 1.19

39 / 75

0.88

0.55 - 1.39

77 / 153

0.95

0.67 - 1.33

 

  ≥ 25

17 / 35

0.81

0.43 - 1.51

5 / 12

0.77

0.25 - 2.39

12 / 23

0.88

0.40 - 1.92

 

  Unknown

10 / 29

  

3 / 7

  

7 / 22

   

  per1 kg / m2 increase

 

1.02

0.98 - 1.07

 

1.03

0.96 - 1.11

 

1.02

0.96 - 1.08

 

  Ptrend

  

0.346

  

0.359

  

0.601

0.88

BMI change (from age 20 to the current age)

 

  < −4

9 / 24

0.72

0.31 - 1.65

5 / 5

1.88

0.49 - 7.19

4 / 19

0.40

0.12 - 1.33

 

  -4 to −2.1

30 / 83

0.80

0.51 - 1.26

16 / 27

1.22

0.62 - 2.42

14 / 56

0.58

0.30 - 1.14

 

  -2 to +1.9

335 / 717

1.00

(ref.)

199 / 402

1.00

(ref.)

135 / 314

1.00

(ref.)

 

  +2 to +4.9

221 / 421

1.05

0.84 - 1.32

86 / 185

0.86

0.61 - 1.22

134 / 233

1.15

0.83 - 1.58

 

  +5 to +7.9

72 / 122

1.30

0.92 - 1.86

20 / 39

1.07

0.56 - 2.05

52 / 83

1.42

0.91 - 2.20

 

  ≥ +8

34 / 28

2.56

1.49 - 4.38

8 / 15

0.96

0.37 - 2.46

26 / 13

4.42

2.10 - 9.28

 

  Unknown

14 / 35

  

6 / 7

  

8 / 28

   

  per1 kg / m2 increase

 

1.06

1.03 - 1.10

 

0.95

0.90 - 1.01

 

1.12

1.07 - 1.17

 

  Ptrend

  

< 0.001

  

0.102

  

< 0.001

< 0.001

  1. ORs were adjusted for age, age at menarche, menopause, parity, age at first live birth, family history of breast cancer, total exercise, hormone use, and referral pattern to our hospital.
  2. aAnalysis of the likelihood test for equality between BMI and menopausal status.
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