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Table 3 Distribution of FRA expression relative to hormone receptor status and tumor grade in a Her2(−) metastatic breast cancer cohort a

From: Folate receptor alpha (FRA) expression in breast cancer: identification of a new molecular subtype and association with triple negative disease

Variable FRA positive FRA negative Total P valueb
  N (%) N (%)   
Marker     
  ER/PR(+) 3 (14%) 20 (86%) 23  
  ER/PR/Her2(−) 19 (50%) 19 (50%) 38 0.0054
     [ER/PR(+) vs ER/PR/Her2(-)]
Tumor Grade     
  Grade 1 3 (30%) 7 (70%) 10  
  Grade 2 11 (28%) 28 (72%) 39 1.0
     (Grade 1 vs Grade 2)
  Grade 3 8 (67%) 4 (33%) 12 0.037
     (Grade 1 or 2 vs Grade 3)
  Total Samples 22 (36%) 39 (64%) 61  
  1. FRA folate receptor alpha, Her2 human epidermal growth factor receptor type 2, ER estrogen receptor, PR progesterone receptor.
  2. a All samples were whole tissue FFPE (formalin-fixed, paraffin-embedded) slides.
  3. b P values calculated via 2X2 contingency table analysis using Fisher’s exact test.
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