Figure 2

FRA staining in normalbreast tissue and DCIS.a Normal breast tissue: strong 3+ membrane staining is seen on the luminal border of secretory cells. Myoepithelial cells in the outer layer of the duct are not stained (x40). b Ductal carcinoma in situ of breast, intermediate grade: the majority of tumor cells reveal 3+ strong or 2+ moderate membrane staining on the luminal and lateral cell borders (x20).