Figure 3

Three cases of CTE with abundant TAR DNA-binding protein of approximately 43 kd (TDP-43) immunoreactivity and motor neuron disease. (A-C) TDP-43 immunoreactive neurofibrillary degeneration in the frontal cortex of 3 cases of CTE + motor neuron disease (whole-mount 50 μm sections immunostained for CP13, original magnification: ×1) (D-F) Tau-positive neurofibrillary tangles, glial tangles, and neuropilneurites are particularly dense at the depth of the cortical sulci (×50). Adapted with permission from McKee et al. 2010 (McKee et al. 2010).