Medicine

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  1. Research

    Correlations of microRNA-124a and microRNA-30d with clinicopathological features of breast cancer patients with type 2 diabetes mellitus

    This study intends to investigate the correlations of miR-124a and miR-30d with clinicopathological features of breast cancer (BC) patients with type 2 diabetes mellitus (T2DM). A total of 72 BC patients with ...

    Yu-Ling Han, Xian-E. Cao, Ju-Xun Wang, Chun-Ling Dong and Hong-Tao Chen

    SpringerPlus 2016 5:2107

    Published on: 22 December 2016

  2. Research

    Effect of various anticoagulants on the bioanalysis of drugs in rat blood: implication for pharmacokinetic studies of anticancer drugs

    Pharmacokinetic studies are vital in development and optimization of drugs. While blood samples can be collected either in EDTA, heparin or citrate containing tubes for the estimation of drug levels in plasma,...

    Preeti Kulkarni, Ashwin Karanam, Murari Gurjar, Sagar Dhoble, Arvind B. Naik, Bhaskar H. Vidhun and Vikram Gota

    SpringerPlus 2016 5:2102

    Published on: 20 December 2016

  3. Research

    Mutation detection in Chinese patients with familial hypercholesterolemia

    Familial hypercholesterolemia (FH) is the first molecularly and clinically characterized genetic disease of lipid metabolism. It is an autosomal dominant disorder with significantly elevated levels of total ch...

    Ran Du, Liang-Liang Fan, Min-Jie Lin, Zhi-Jian He, Hao Huang, Ya-Qin Chen, Jing-Jing Li, Kun Xia, Shui-Ping Zhao and Rong Xiang

    SpringerPlus 2016 5:2095

    Published on: 12 December 2016

  4. Research

    Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis

    Sepsis is one of the most common diseases that seriously threaten human health. Although a large number of markers related to sepsis have been reported in the last two decades, the diagnostic accuracy of these...

    Yong Liu, Jun-huan Hou, Qing Li, Kui-jun Chen, Shu-Nan Wang and Jian-min Wang

    SpringerPlus 2016 5:2091

    Published on: 12 December 2016

  5. Review

    Nephrotoxicity of methadone: a systematic review

    Methadone is commonly administered for chronic pain relief and treatment of opioid dependence. Concurrent with its increased consumption, toxicities and fatalities have increased. One of the adverse effects of...

    Samira Alinejad, Kazem Ghaemi, Mohammad Abdollahi and Omid Mehrpour

    SpringerPlus 2016 5:2087

    Published on: 9 December 2016

  6. Research

    Efficacy of triple antiemetic therapy (palonosetron, dexamethasone, aprepitant) for chemotherapy-induced nausea and vomiting in patients receiving carboplatin-based, moderately emetogenic chemotherapy

    Chemotherapy-induced nausea and vomiting (CINV) is a major adverse toxicity of cancer chemotherapy. Recommended treatments for prevention of CINV vary among published guidelines, and optimal care for CINV caus...

    Toshimichi Miya, Kunihiko Kobayashi, Mitsunori Hino, Masahiro Ando, Susumu Takeuchi, Masahiro Seike, Kaoru Kubota and Akihiko Gemma

    SpringerPlus 2016 5:2080

    Published on: 7 December 2016

  7. Research

    Simultaneous detection of influenza A subtypes of H3N2 virus, pandemic (H1N1) 2009 virus and reassortant avian H7N9 virus in humans by multiplex one-step real-time RT-PCR assay

    Influenza A virus is a leading causative pathogen of human acute respiratory infection. Recently, the co-circulation of pandemic (H1N1) 2009 and seasonal H3N2 viruses was reported, and sporadic cases with rea...

    Dawei Cui, Dejian Zhao, Guoliang Xie, Xianzhi Yang, Zhaoxia Huo, Shufa Zheng, Fei Yu and Yu Chen

    SpringerPlus 2016 5:2054

    Published on: 1 December 2016

  8. Research

    Direct new oral anticoagulants: follow-up, guidelines and bleeding complications in general practice—a survey of Swiss general internal medicine practitioners

    The present study investigated how much Swiss general internal medicine practitioners (GPs) know about new direct oral anticoagulants (NOACs), particularly the relevant guidelines, follow-up tests, dosing adj...

    Thomas C. Sauter, Carlo Melis, Wolf E. Hautz, Meret E. Ricklin and Aristomenis K. Exadaktylos

    SpringerPlus 2016 5:2030

    Published on: 29 November 2016

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