Parameters | Plasma pharmacokinetics | Brain pharmacokinetics | ||||
---|---|---|---|---|---|---|
Quinidine | With silymarin | With quercetin | Quinidine | With silymarin | With quercetin | |
Dose (mg/kg) | 5 | 10 | 10 | 5 | 10 | 10 |
Half life (h) | 1.43 | 1.73 | 1.86 | 1.50 | 1.95 | 1.91 |
Tmax (h) | 0.66 | 0.50 | 0.50 | 0.80 | 0.50 | 0.83 |
Cmax (ng/mL) | 209.16 | 364.48 | 244.80 | 115.40 | 301.60 | 235.73 |
AUClast (h ng/mL) | 496.40 | 680.43 | 445.29 | 211.40 | 635.15 | 390.09 |
AUCINF_obs (h ng/mL) | 513.40 | 704.07 | 463.55 | 251.20 | 682.40 | 405.64 |