Table 1 Baseline demographics and disease characteristics
Parameter | 24 weeks lambda/RBV N = 353 | 12 weeks lambda/RBV + DCV N = 349 | 24 weeks alfa/RBV N = 172 |
|---|---|---|---|
Age, mean (range), years | 48 (20, 72) | 47 (18, 74) | 46 (21, 73) |
Male, n (%) | 210 (59) | 195 (56) | 93 (54) |
Race/ethnicity, n (%) | |||
White | 232 (66) | 226 (65) | 111 (64) |
Black/African American | 4 (1) | 5 (1) | 3 (2) |
Asian | 113 (32) | 118 (34) | 55 (32) |
Other | 4 (1) | 0 | 3 (2) |
Hispanic/Latino ethnicity | 45 (13) | 48 (14) | 17 (10) |
BL HCV RNA, mean (SD) (log10 IU/mL) | 6 (1) | 6 (1) | 6 (1) |
HCV RNA distribution (IU/mL) | |||
≥800,000 | 269 (76) | 276 (79) | 132 (77) |
HCV genotype, n (%) | |||
Genotype 2 | 183 (52) | 184 (53) | 91 (53) |
Genotype 3 | 170 (48) | 165 (47) | 81 (47) |
Cirrhosis, n (%) | 25 (7) | 26 (7) | 14 (8) |
By biopsy | 9 (3) | 4 (1) | 2 (1) |
By FibroScan | 16 (5) | 22 (6) | 12 (7) |
IL28B genotype (RS12979860), n (%) | |||
CC | 180 (51) | 192 (55) | 94 (55) |
CT | 145 (42) | 126 (36) | 68 (40) |
TT | 27 (8) | 28 (8) | 10 (6) |
Body mass index >30 kg/m2, n (%) | 54 (15) | 62 (18) | 21 (12) |