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Table 1 Leptin (ng/mL) at admission (0–48 h) after SAH

From: Leptin levels after subarachnoid haemorrhage are gender dependent

Parameter

Number of samples

Leptin (ng/mL)

Sig.

Gender

 Female/male

37/17

35.5 ± 25.5/14.4 ± 7.8

<0.0001

Agea

 Female

  ≤59/>59

18/19

23.8 ± 16.9/46.5 ± 27.6

ns

 Male

  ≤63/>63

8/9

15.6 ± 10.4/11.3 ± 6.1

ns

BMIb

 Female

  ≤25/>25

20/17

27.7 ± 19.4/28.3 ± 2.9

<0.05

 Male

  ≤25/>25

11/6

24.5 ± 16.4/26.9 ± 1.6

ns

Hypertensionc

 Female

  Yes/no

10/27

33.1 ± 18.0/36.3 ± 28.0

ns

 Male

  Yes/no

8/9

17.8 ± 9.7/9.3 ± 4.6

<0.05

Hunt and Hessd

 Female

  1–2/3–5

17/20

38.9 ± 29.1/32.6 ± 22.2

ns

 Male

  1–2/3–5

12/5

12.7 ± 9.2/14.8 ± 6.7

ns

GOSe

 Female

  1–3/4–5

8/29

46.7 ± 33.9/32.4 ± 22.4

ns

 Male

  1–3/4–5

6/11

17.7 ± 11.6/10.9 ± 5.3

ns

Deceasedf

 Female

  Yes/no

4/33

44.6 ± 33.5/31.9 ± 22.5

<0.05

 Male

  Yes/no

3/14

16.2 ± 7.8/12.7 ± 8.7

ns

SOFAg

 Female

  0–2/3–4

11/26

39.0 ± 28.2/34.0 ± 24.7

ns

 Male

  0–2/3–4

4/13

12.9 ± 5.2/13.4 ± 9.4

ns

  1. In two female patients, blood samples from 0 to 48 h are not obtained
  2. aMedian age in female patients was 59 (31–82) and in male patients 63 (26–77) years
  3. b BMI body mass index; females patients median 24 (18–44), male patients median 25 (22–30)
  4. cPatients with pharmacologically treated hypertension at admission
  5. d H&H Hunt and Hess score for classifying the severity of the SAH; 1 asymptomatic/minimal headache; 2 moderate/severe headache, no neurological deficit other than cranial nerve palsy; 3 drowsiness, confusion or mild focal deficit; 4 stupor, moderate to severe hemiparesis; 5 deep coma, moribund appearance. H&H 1–2 = less severe clinical condition, H&H = 3–5 severe clinical condition
  6. e GOS Glasgow outcome scale. (1) Dead, (2) Vegetative state, (3) Severe disability, (4) Moderate disability, (5) Good recovery. GOS 1–3 = Unfavourable outcome, GOS 4–5 = favourable outcome
  7. fSeven patients died during the study period, three males and four females. Median time to death was 20 (9–39) days
  8. gSequential Organ Failure Assessment (SOFA) scores organ failure from zero; no organ failure, to four; pronounced organ failure. Six different organ systems are scored; respiration, haematology, hepatic, cardiovascular, renal and central nervous system (CNS). The worst value obtained during a 24-h period is used. In this study the SOFA CNS score was not used, Patients were divided in; severe organ failure ≥3 and not severe organ failure 0–2 at any time during the period studied