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Table 8 HoloTC reference intervals and cut-offs

From: Holotranscobalamin (HoloTC, Active-B12) and Herbert’s model for the development of vitamin B12 deficiency: a review and alternative hypothesis

Reference

Reference interval (pmol/L)

Cut-off (pmol/L)

Abbott Laboratories (2006)

 

37

Abbott Laboratories (2011)

 

35

Al Aisari et al. (2010)

9–123

 

Aparicio-Ugarriza et al. (2014)

20–50 (literature review)

 

Augoustides-Savvopoulou et al. (2007)

 

35

Axis-Shield and Abbott Laboratories (2006a)

 

35

Axis-Shield (2007a)

 

35

Axis-Shield (2007b)

 

37

Bamonti et al. (2010)

 

40

Black et al. (2006)

23–100

 

Brady et al. (2007)

 

35

Chen et al. (2005)

46–356

30

Clarke et al. (2007)

 

45

Fragasso et al. (2012)

 

35

Goringe et al. (2006)

16 (diagnostic), 38 (laboratory)

 

Green (2007, 2011)

 

35

Heil et al. (2012)

 

32

Herbert (1987)

 

22

Herbert (1994)

 

37

Herrmann et al. (2003a, b, 2005)

 

35

Herrmann and Obeid (2007)

40–70 “Grey zone”

 

Herrmann and Obeid (2008)

 

35

Herrmann and Obeid (2013)

22–76 “Grey zone”

 

Herrmann et al. (2003a)

 

35

Herrmann et al. (2005)

 

35

Hooshmand et al. (2012)

 

35

Hvas and Nexo (2003)

 

50

Hvas and Nexo (2005)

 

40

Lee et al. (2009)

 

42.48

Lindemans et al. (2007)

20–122

 

Lindgren et al. (1999)

35–160

 

Lloyd-Wright et al. (2003)

<25 likely, >50 unlikely B12 deficiency

 

Lobreglio et al. (2008)

 

35

Loikas et al. (2003, 2007a, b)

 

37

Loikas (2007)

37–171

 

Miller et al. (2006)

 

35

Morkbak et al. (2005)

40, 11–41 (literature review)

37

Morkbak et al. (2007)

40–150

 

Nexo et al. (2002a)

40–150

 

Nexo et al. (2002b)

40–150

 

Nexo and Hoffmann-Lücke (2011)

40–200

 

Obeid and Herrmann (2007a, 2007b)

 

35

Palacios et al. (2013)

 

35

Pry (2006)

 

37

Refsum et al. (2006)

42–157

 

Remacha et al. (2014)

 

33.5

Schrempf et al. (2011)

 

42

Serefhanoglu et al. (2008)

 

37

Sobczyńska-Malefora et al. (2014)

25–50 “poor predictor MMA”

 

Valente et al. (2011)

20–30 “indeterminate zone”

20

van Asselt et al. (2003)

38–113

 

Vanpoucke et al. (2007)

 

37

Woo et al. (2010)

 

35