Fig. 1

Unsupervised hierarchical clustering of 28 luminal BCs based on 1264 differently methylated CpGs between breast tumors and normal breast. The dendrogram was built with the Manhattan distance as dissimilarity metric and the Ward. 2 linkage method for definition of the structure. Values on the edges of the clustering are p values (%). Red values on de egde of the clustering are (Approximately Unbiased) p values. AU values were computed by multiscale bootstrap resampling. R-cran “pvclust” package was used for assessing the robustness of these hierarchical clusters through multiscale bootstrap resampling of the genes