Table 2 Polymorphisms of the CYP enzymes CYP2C9, CYP2C19 and CYP2D6 (n = 51)
Enzyme | Enzyme activity | Genotype | Number (%) | 95 % CI, % |
|---|---|---|---|---|
CYP2C9 | Normal | *1/*1 | 37 (73) | 58–84 |
Intermediate | *1/*2, *1/*3 | 10 (20) | 11–35 | |
Poor | *2/*2, *2/*3,*3/*3 | 4 (8) | 1–16 | |
CYP2C19 | Normal | *1/*1 | 20 (39) | 26–54 |
Approximately normal | *1/*17, *2/*17 | 18 (35) | 22–50 | |
Intermediate | *1/*2,*1/*3 | 10 (20) | 9–33 | |
Poor | *2/*2 | 2 (4) | 0–13 | |
Increased | *17/*17 | 1 (2) | 0–10 | |
CYP2D6 | Normal | *1/*1 | 13 (26) | 14–40 |
Approximately normal | *1/*9, *1/*41 | 10 (20) | 10–33 | |
Intermediate | *1/*3, *1/*4, *1/*5, *1/*6, *9/*9, *10/*10, *10/*41, *4/*41 | 24 (47) | 33–62 | |
Poor | *3/*4, *4/*4, *4/*5, *5/*6 | 4 (8) | 2–19 |