Skip to main content

The prevalence of lymphoedema in women who attended an information and exercise class to reduce the risk of breast cancer-related upper limb lymphoedema

Abstract

Breast cancer-related upper limb lymphoedema (BCRL) affects approximately 20 % of women undergoing axillary intervention. Women who attended a “reducing your risk of lymphoedema” class, including exercise instruction, anecdotally reported positive BCRL outcomes. The aim of this study was to examine BCRL outcomes and perceived benefit for attendees at a “reducing your risk of lymphoedema” class between 2000 and 2005. A cross-sectional study was conducted in two parts: (1) self-report questionnaire regarding lymphoedema status and benefit received from class and exercise programme; (2) clinical evaluation and objective measurement to confirm BCRL. 46 women completed questionnaires; 40 continued to clinical evaluation and objective measurement. BCRL prevalence defined as ≥10 % excess limb volume was only 5 %, although clinician judgement identified 23 % with arm lymphoedema and 8 % with lymphoedema limited to the hand. Clinician judgement correlated highly with patient self-report (Kappa = 0.833, p = 0.000). All women found the class beneficial, reporting increased confidence to return to normal life and a wide range of activities/exercise. We conclude that prevalence of BCRL should be determined by both clinical judgement and objective measurement to avoid underestimation. The benefit of group education with a lymphoedema expert and of exercise instruction should be further explored, and the potential for exercise to reduce BCRL prevalence should be examined.

Background

Lymphoedema is a common consequence of breast cancer treatment affecting approximately 20 % of women undergoing axillary intervention, with the majority developing swelling within 2 years (Disipio et al. 2013). The impact of breast cancer-related upper limb lymphoedema (BCRL) on the survivor is significant, including physical changes, impairment to function and daily life activities, challenges for work, social and leisure activities, and financial implications (Shih et al. 2009; Carter 1997; Fu 2008; Radina 2009). BCRL causes considerable psychological distress (Fu et al. 2013), and can alter body image and act as a visible reminder of breast cancer and its treatment (Vassard et al. 2010).

Women in the UK at risk of developing BCRL are routinely offered verbal and written advice regarding care and use of the arm (e.g. leaflets from Breast Cancer Care, Lymphoedema Support Network, Macmillan Cancer Support), with many services offering additional group education sessions. As part of a review of breast cancer care at our hospital we wished to explore the potential impact on BCRL outcome of a proactive approach to advice and education regarding exercise.

The role of exercise and movement to influence lymphatic and venous drainage is well recognised (Foldi and Foldi 2012; Lymphoedema Framework 2006; International Society of Lymphology 2013). It is now accepted that appropriately performed exercise does not cause or exacerbate BCRL (Cheema et al. 2014; Kwan et al. 2011; Stuiver et al. 2015). However, for many years women with and at risk of developing BCRL were advised to avoid any strenuous activity or exercise (Cemal et al. 2011; Lee et al. 2009; Nielsen et al. 2008), and many UK women still report precautionary behaviours; these include limiting use of their affected arm, and a desire for greater guidance regarding how to safely return to pre-treatment exercise and activity levels (anecdotal evidence).

We decided to review the outcomes of a group of women who had attended a “reducing your risk of lymphoedema” education and advice class (taught by author EJ) between 2000 and 2005; to our knowledge, none of the women subsequently reported development of BCRL. The class had included teaching of a simple exercise programme which had originally been developed by the author (EJ) in 2000 at the request of women with BCRL who wanted to know how to safely return to pre-treatment exercise; they wished to recommence activities such as gym, playing tennis, golf, without triggering or exacerbating BCRL. So we wanted to know whether the “at risk” group had in fact achieved better lymphoedema outcomes than might be expected in such a group. Also, we knew that some women with established BCRL (n = 21) had used the bespoke exercise programme added to usual care and demonstrated a small but clinically and statistically significant greater reduction in excess limb volume (ELV) when compared to usual care alone (Jeffs and Wiseman 2013).

The primary objective of this study was to determine prevalence of clinically detectable BCRL in women who attended a “reducing your risk of lymphoedema” class between 2000 and 2005. In addition, we intended to observe how ELV and participant perception of BCRL compared with clinician assessment, so secondary objectives included determining the number of women with ELV ≥10 % and patient-perceived BCRL, and the agreement between all three methods. Finally, we wanted to know the patient-perceived benefit of attending the “reducing your risk of lymphoedema” class.

Participants and methods

The cross-sectional study was designed in two parts:

  1. 1.

    Self-report questionnaire to ascertain patient report of BCRL, and perceived benefit of attending the “reducing your risk of lymphoedema” class and undertaking the exercise programme;

  2. 2.

    Clinical assessment to confirm presence of BCRL and determine percentage ELV.

Participants

The participants were women who had attended a “reducing your risk of lymphoedema” class, taught by the author (EJ) at a London breast cancer support charity between 2000 and 2005 (Jeffs 2006). The 1½ h class consisted of two parts: (1) explanation of BCRL, risk, and measures that may reduce risk of developing BCRL; (2) demonstration and practice of a simple 10–15 min exercise routine for daily home use. The exercise routine consisted of a proximal to distal sequence of deep breathing and gravity-resistive isotonic arm exercises (flexibility and strengthening) designed to stimulate lymphatic and venous return. The class encouraged a return to pre-treatment exercise and activities at a time when women receiving breast cancer treatment in the UK were routinely advised not to lift more than 3 lb weight.

Records of the London breast cancer support charity were examined, identifying attendees at a total of 13 lymphoedema awareness classes (see Fig. 1). Women were excluded if they could not be contacted, were deceased, not well enough to participate, or had attended a class not taught by the author (EJ). As it was likely that, unbeknownst to the charity, some women were deceased or suffering from progressive disease (Cancer Research UK 2015), we requested individual primary care providers (GPs) to confirm whether their patient was well enough to participate; 83 GPs (91 %) responded (see Fig. 1).

Fig. 1
figure 1

Participant flow through trial

Data collection

In 2012, questionnaires were sent to 77 women with an explanatory letter, study information sheet, and stamped addressed envelope to return their completed questionnaire. One reminder letter was sent 6 weeks later with another copy of questionnaire and study information.

The questionnaire contained 27 items addressing three main areas: (1) breast cancer treatment; (2) development of swelling and associated symptoms; (3) views on “reducing your risk of lymphoedema” class and perceived benefit of exercise programme. It combined tick boxes with free text and additional space for further comments. Receipt of completed questionnaire was considered consent to part one of the study.

Each woman who returned a completed questionnaire was invited to attend for clinical assessment (study part two). One reminder letter was sent to those who did not respond or failed to attend a booked appointment.

Clinical assessment to determine the presence of BCRL followed the assessment method used in the author’s (EJ) clinical practice and previous research (Jeffs and Wiseman 2013), addressing:

  • baseline demographics: age, weight, height, ethnicity, occupation, activity level;

  • medical history: participant self-report of breast cancer treatment, current health status, onset and development of swelling, precipitating factors, lymphoedema precautions taken;

  • clinical examination of both limbs to determine presence of oedema;

  • participant perception of current arm symptoms: swelling, ache, heaviness, pain, numbness, tingling;

  • clinical measurements:

    • limb volume, by Perometry, an infrared measuring device (Lee et al. 2011);

    • shoulder extension and abduction, using goniometry (Jeffs and Wiseman 2013; Valentine and Lewis 2006);

    • quality of life using LYMQOL, a lymphoedema-specific arm questionnaire (Keeley et al. 2010);

    • self-report arm and hand function, using QuickDASH (Kennedy et al. 2013).

Diagnosing lymphoedema

For the purpose of this study, the presence of BCRL was determined by three methods used in incidence and prevalence studies (Armer and Stewart 2005; Disipio et al. 2013; Hayes et al. 2008a):

  1. 1.

    clinician judgement, with the presence of one or more symptom of oedema regardless of severity: decreased visibility of veins, increased thickness of skin and subcutis, fullness of tissues or smoothing of natural limb contours, pitting oedema (Stanton et al. 2006);

  2. 2.

    at least 10 % ELV, as measured by the Perometer;

  3. 3.

    patient self-report.

Analysis

Data were analysed to determine participant homogeneity and associations for diagnosis of lymphoedema by three methods: (1) clinical judgement, (2) objective limb volume measurement, (3) patient report. Sensitivity and specificity were calculated for method (1) versus (2) and (1) versus (3), with kappa statistics calculated for all 3 methods as well as for each pair (Landis and Koch 1977).

Statistical analysis was carried out using SPSS version 20 (IBM, USA), with significance set at p < 0.05.

Ethical issues

Approval was obtained from the National Research Ethics Service (NRES Committee London-Dulwich) and sponsoring hospital’s Research and Development department prior to commencement of the study. The study was conducted in compliance with the study protocol, ethical standards laid down in the 1964 Declaration of Helsinki and Good Clinical Practice guidelines for research. All participants gave informed written consent prior to inclusion in the study.

Results

Forty-six women (60 %) completed questionnaires and 40 women (52 %) underwent a clinical assessment, a conversion rate of 87 %. Demographic and clinical characteristics for the 40 women (study part two) are shown in Tables 1 and 2. The only significant difference between women with and without clinician-determined lymphoedema were ELV and duration of lymphoedema.

Table 1 Demographic characteristics of total group and according to presence of clinician-determined BCRL
Table 2 Clinical characteristics of total group and according to presence of clinician-determined BCRL

Lymphoedema prevalence

Nine women (23 %) had some degree of clinician-determined arm lymphoedema, which was also self-reported (see Table 3); four women (10 %) reported BCRL developed prior to attending the class. Only two women (5 %) reached the common diagnostic threshold of ≥10 % ELV, both of whom developed BCRL since attending the class. A further three women (8 %) had lymphoedema limited to the hand, also self-reported; thus the overall clinician-determined prevalence of BCRL was 30 %. Another three women self-reported current lymphoedema which was judged by the clinician not to be BCRL: two women had bilateral hand oedema likely due to arthritis, and the third woman experienced only the sensation of swelling in an area of paraesthesia in her posterior upper arm.

Table 3 Level of agreement between clinically-determined lymphoedema and other methods

A further twelve women (30 %) without any current symptoms reported previous experience of lymphoedema affecting the hand, arm, axilla or breast; it is not known whether symptoms pre or post-dated attendance at the class. Eight women received lymphoedema treatment which included hosiery; five women reported full resolution achieved within 1 month. Three of the four women who underwent sentinel node biopsy experienced transient oedema, which they did not consider to be lymphoedema as it spontaneously resolved within 1 month.

Of the six women (13 %) who completed questionnaires but did not attend the clinical assessment, three had reported current swelling which could not be verified, two reported swelling now resolved, and one had never experienced swelling.

Comparing diagnostic methods

The diagnostic method of ≥10 % ELV was 100 % specific (see Table 3) but had low sensitivity (17 %), identifying only two of the nine women with clinician-determined arm lymphoedema (k = 0.217, p = 0.029). There was a substantial level of agreement between clinician-determined swelling and patient self-report of current swelling (k = 0.833, p = 0.000, see Table 3).

Evaluating the “reducing your risk of lymphoedema” class and exercise programme

All 46 women (100 %) responding to the questionnaire found the class beneficial. They particularly valued access to a knowledgeable health care professional, evidence-based information, specific advice regarding aspects of risk reduction and how to manage BCRL should it develop, the opportunity to share knowledge and experiences with other women in the same situation. They firmly believed their increased knowledge helped to prevent or minimise problems, supported their return to active daily life, and provided a strategy for self-management of risk and any subsequent BCRL. Only five women (11 %) reported both benefit from increased knowledge and alarm from heightened awareness. Forty-five women (98 %) recommended similar sessions and information be made available to everyone undergoing breast cancer treatment; for example:

“I hope that lymphoedema is taken more seriously by the medical establishment and that information & classes etc. now form part of a standard & holistic treatment plan” (ID38).

Most women (76 %) suggested the class should ideally be offered post-operatively; 25 women (54 %) suggested around 1 month and 11 women (24 %) suggested several months following surgery. Only 9 women (20 %) suggested it was best offered preoperatively, although three women thought offering both pre and postoperative classes was preferable. Several women suggested individual preference would affect the point at which both written information and class instruction would be most beneficial.

Thirty-seven women (80 %) reported benefit from being taught the exercise programme: 26 women (65 %) did the exercise programme for at least 1 month following the class, with 13 women (33 %) continuing the programme for at least 6 months (see Table 4). Some women reported still using the exercise programme whenever they became more aware of symptoms. Only one woman (2 %) stated the exercise programme was not helpful, although seven women (14 %) either could not remember the programme or recall whether it was beneficial. Twenty-nine women (63 %) indicated specific personal benefits, particularly increased confidence to know what they could safely do; the benefits include:

Table 4 Reported precautionary behaviour and activities following lymphoedema awareness class

“Relieve symptoms/aches and pains/tense muscles” (ID16,42,44),

“Eased movement of arms” (ID31),

“Gained strength in my arm” (ID40),

“Stretching affected arm in all directions” (ID37),

“I was able to see improvement” (ID46).

Many women wrote that they believed the knowledge they gained from the class helped to either prevent development of lymphoedema or resolve any swelling that did develop; for example:

“Due to the exercises & other activities I’ve listed lymphoedema is minimum” (ID8);

“Probably the most useful session I attended post surgery. Helped me avoid lymphoedema” (ID23).

The women also wrote about gaining from the class and exercise programme confidence to return to normal life and recommence a wide range of activities they might otherwise not have done. The exercise programme was used by some women as a bridge to other sports and exercise programmes; for example, following a return to Yoga or Pilates they gradually stopped doing the lymphoedema exercises. They reported a wide range of current active sports and hobbies, including squash, tennis, golf, gym, body-building, pole-walking, kayaking. Ten women (22 %) reported employment or a regular hobby requiring repetitive hand and arm movements, including pottery, glass-casting, mosaics, knitting, ceramics/clay-throwing, painting, drawing, sewing, woodcarving, upholstering furniture. Although the majority were very active, five women (11 %) volunteered that they had chosen to avoid or limit certain activities.

Discussion

Our finding of 5 % BCRL prevalence, defined as ≥10 % ELV, is lower than might be expected when compared with other cross-sectional studies similarly defining BCRL (Disipio et al. 2013). When determined by clinician judgement, we found 23 % prevalence of arm lymphoedema, which increased to 30 % prevalence with inclusion of lymphoedema limited to the hand, with a median 4.8 % ELV. In the absence of a definitive reference method for determining BCRL, it is difficult to determine whether a method is under or over-diagnosing lymphoedema (Ward et al. 2015). However, we support the view that defining BCRL by limb volume difference underestimates the extent of the problem (Stanton et al. 2006; Armer and Stewart 2005; Disipio et al. 2013) and suggest that clinical judgement should be included to ensure appropriate diagnosis.

Clinician-judgement is highly interpretive. We wanted to capture all cases of lymphoedema so there was no threshold for inclusion of clinical symptoms. However, diagnostic parameters used by clinicians in other studies were often not specified thus making any meaningful comparison difficult (e.g. Hayes et al. 2008b; Ahmed 2006; Schmitz et al. 2010; Querci della Rovere et al. 2003). The challenge remains to quantify subjective diagnostic criteria to allow universal application and meaningful comparison of findings.

Reported incidence/prevalence of BCRL varies widely, influenced by the definition of lymphoedema used and characteristics of different assessment methods (Armer and Stewart 2005; Disipio et al. 2013; Hayes et al. 2005; O’Toole et al. 2013). Our study found that patient self-report correlated highly with clinician judgement of BCRL, which supports the view that the patient report should also be considered when determining the presence of BCRL (Armer and Stewart 2005; Paskett et al. 2012). A tool to aid self-report diagnosis may well have reduced the overestimation of self-reported lymphoedema (8 %) in our study (Armer et al. 2003; Norman et al. 2001). Other objective measures such as bioimpedance ratios and limb volume change (using a pre-surgery baseline) have been reported as beneficial in the early detection of lymphoedema (Perdomo et al. 2014) but, in the absence of a definitive reference method, their precision as a diagnostic method have yet to be determined.

There is a developing body of evidence to support the safety and benefit of exercise for women with and at risk of developing BCRL (Box et al. 2002; Kilbreath et al. 2012; Schmitz et al. 2010; Lacomba et al. 2010); this information this was not available at the time of the classes in 2000–2005. There is now recognition of the importance of conditioning the limb to cope with day-to-day activities and emphasising what can and should be done, rather than adopting a precautionary and restrictive approach to daily activity (Miller 1998; National Institute for Health and Clinical Excellence 2014; Schmitz et al. 2009, 2010; Jeffs et al. 2015). Several studies have shown benefit from exercise instruction combined with education about BCRL (Fu et al. 2014; Sisman et al. 2012). Group education about the importance of regular arm flexibility and strengthening exercises (in addition to general activity and maintaining range of shoulder motion) is a relatively low-cost way to inform women about positive approaches to daily living with or at risk of developing BCRL, rather than merely advising what they can safely do.

Lymphoedema awareness sessions have the potential to empower women to live well and live normally following breast cancer treatment, and provide guidance regarding pacing of exercise and activities. Our findings highlight the great value women place on this opportunity to gain evidence-based information and advice from a lymphoedema expert, with practical guidance to help them bridge the gap between post-operative exercises and various sporting activities and strenuous work roles. Women value expert information which increases their confidence to return to normal activity (Jeffs et al. 2015), but are frustrated by lack of information and poor quality or inaccurate information (Lee et al. 2010). In a study of 136 women following breast cancer treatment, those who received information about lymphoedema experienced fewer lymphoedema symptoms (Fu et al. 2010), although no conclusions could be drawn about the optimal format of information provision.

The study was not designed to identify causality, however, we can speculate regarding possible reasons for the low prevalence of BCRL defined by ELV. The women believed the education and exercise programme were very beneficial, particularly with regard to information about actions to minimise or prevent BCRL symptoms. Other factors will also have contributed to the BCRL outcome, including provision of lymphoedema treatment; the majority of those who had experienced BCRL had received some form of lymphoedema treatment.

The combination of patient report, clinical assessment and objective measurement to determine prevalence provides a strong level of confidence in the findings. We achieved a reasonable response rate to the questionnaire (60 %) and a high conversion rate (87 %) to the assessment phase; however, we do not know what happened to the 31 women (40 %) who did not return a completed questionnaire, nor were we able to confirm the self-report of the six women who completed questionnaires (part 1) but did not attend the assessment (part 2). The study population included women whose attendance at the class had been recommended by the local breast cancer service, and also women who had actively sought out the lymphoedema awareness class following breast cancer treatment elsewhere in London and the UK; we did not collect information about the hospital where the women received their cancer treatment.

Our findings have led us to conclude that clinician-judgement should be combined with objective measurement of ELV to avoid underestimation of BCRL, and to detect mild arm lymphoedema and also lymphoedema limited to the hand; in addition, patient self-report should be taken into consideration. Further research should be conducted to determine the protective and treatment benefits of providing group education from a lymphoedema expert and of teaching specific exercise; this is in addition to providing written information regarding lymphoedema care and general exercise.

Abbreviations

BCRL:

breast cancer-related upper limb lymphoedema

ELV:

excess limb volume

GP:

general practitioner

References

  • Ahmed (2006) Randomized controlled trial of weight training and lymphedema in breast cancer survivors. J Clin Oncol 24(18):2765–2772. doi:10.1200/jco.2005.03.6749

    Article  Google Scholar 

  • Armer JM, Stewart BR (2005) A comparison of four diagnostic criteria for lymphedema in a post-breast cancer population. Lymphatic Res Biol 3(4):208–217. doi:10.1089/lrb.2005.3.208

    Article  Google Scholar 

  • Armer JM, Radina ME, Porock D, Culbertson SD (2003) Predicting breast cancer-related lymphedema using self-reported symptoms. Nurs Res 52(6):370–379

    Article  Google Scholar 

  • Box RC, Reul-Hirche HM, Bullock-Saxton JE, Furnival CM (2002) Physiotherapy after breast cancer surgery: results of a randomised controlled study to minimise lymphoedema. Breast Cancer Res Treat 75(1):51–64

    Article  Google Scholar 

  • Cancer Research UK (2015) Breast cancer survival. http://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/breast-cancer#heading-Three. Accessed 30 Nov 2015

  • Carter BJ (1997) Women’s experiences of lymphedema. Oncol Nurs Forum 24(5):875–883

    Google Scholar 

  • Cemal Y, Pusic A, Mehrara BJ (2011) Preventative measures for lymphedema: separating fact from fiction. J Am Coll Surg 213(4):543–551. doi:10.1016/j.jamcollsurg.2011.07.001

    Article  Google Scholar 

  • Cheema BS, Kilbreath SL, Fahey PP, Delaney GP, Atlantis E (2014) Safety and efficacy of progressive resistance training in breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat 148(2):249–268. doi:10.1007/s10549-014-3162-9

    Article  Google Scholar 

  • Disipio T, Rye S, Newman B, Hayes S (2013) Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis. Lancet Oncol 14(6):500–516. doi:10.1016/S1470-2045(13)70076-7

    Article  Google Scholar 

  • Foldi M, Foldi E (eds) (2012) Foldi’s textbook of lymphology: for physicians and lymphedema therapists, 3rd edn. Urban and Fischer, Munich

    Google Scholar 

  • Fu M (2008) Women at work with breast cancer-related lymphoedema. J Lymphoedema 3(1):20–25

    Google Scholar 

  • Fu MR, Chen CM, Haber J, Guth AA, Axelrod D (2010) The effect of providing information about lymphedema on the cognitive and symptom outcomes of breast cancer survivors. Ann Surg Oncol 17(7):1847–1853. doi:10.1245/s10434-010-0941-3

    Article  Google Scholar 

  • Fu MR, Ridner SH, Hu SH, Stewart BR, Cormier JN, Armer JM (2013) Psychosocial impact of lymphedema: a systematic review of literature from 2004 to 2011. Psycho-Oncology 22(7):1466–1484. doi:10.1002/pon.3201

    Article  Google Scholar 

  • Fu MR, Axelrod D, Guth AA, Cartwright F, Qiu Z, Goldberg JD, Kim J, Scagliola J, Kleinman R, Haber J (2014) Proactive approach to lymphedema risk reduction: a prospective study. Ann Surg Oncol 21(11):3481–3489. doi:10.1245/s10434-014-3761-z

    Article  Google Scholar 

  • Hayes S, Cornish B, Newman B (2005) Comparison of methods to diagnose lymphoedema among breast cancer survivors: 6-month follow-up. Breast Cancer Res Treat 89(3):221–226. doi:10.1007/s10549-004-2045-x

    Article  Google Scholar 

  • Hayes S, Janda M, Cornish B, Battistutta D, Newman B (2008a) Lymphedema secondary to breast cancer: how choice of measure influences diagnosis, prevalence, and identifiable risk factors. Lymphology 41(1):18–28

    Google Scholar 

  • Hayes SB, Freedman GM, Li TY, Anderson PR, Ross E (2008b) Does axillary boost increase lymphedema compared with supraclavicular radiation alone after breast conservation? Int J Radiat Oncol Biol Phys 72(5):1449–1455. doi:10.1016/j.ijrobp.2008.02.080

    Article  Google Scholar 

  • International Society of Lymphology (2013) The diagnosis and treatment of peripheral lymphedema: 2013 consensus document of the international society of lymphology. Lymphology 46(1):1–11

    Google Scholar 

  • Jeffs E (2006) Treating breast cancer-related lymphoedema at the London Haven: clinical audit results. Eur J Oncol Nurs 10(1):71–79. doi:10.1016/j.ejon.2005.02.005

    Article  Google Scholar 

  • Jeffs E, Wiseman T (2013) Randomised controlled trial to determine the benefit of daily home-based exercise in addition to self-care in the management of breast cancer-related lymphoedema: a feasibility study. Support Care Cancer 21(4):1013–1023. doi:10.1007/s00520-012-1621-6

    Article  Google Scholar 

  • Jeffs E, Ream E, Shewbridge A, Cowan-Dickie S, Crawshaw D, Huit M, Wiseman T (2015) Exploring patient perception of success and benefit in self-management of breast cancer-related arm lymphoedema. Eur J Oncol Nurs. doi:10.1016/j.ejon.2015.08.001

    Google Scholar 

  • Keeley V, Crooks A, Veigas D, Riches K, Hilliam R (2010) A quality of life measure for limb lymphoedema (LYMQOL). J Lymphoedema 5(1):26–37

    Google Scholar 

  • Kennedy CA, Beaton DE, Smith P, Van Eerd D, Tang K, Inrig T, Hogg-Johnson S, Linton D, Couban R (2013) Measurement properties of the QuickDASH (disabilities of the arm, shoulder and hand) outcome measure and cross-cultural adaptations of the QuickDASH: a systematic review. Qual Life Res 22(9):2509–2547. doi:10.1007/s11136-013-0362-4

    Article  Google Scholar 

  • Kilbreath SL, Refshauge KM, Beith JM, Ward LC, Lee M, Simpson JM, Hansen R (2012) Upper limb progressive resistance training and stretching exercises following surgery for early breast cancer: a randomized controlled trial. Breast Cancer Res Treat 133(2):667–676. doi:10.1007/s10549-012-1964-1

    Article  Google Scholar 

  • Kwan ML, Cohn JC, Armer JM, Stewart BR, Cormier JN (2011) Exercise in patients with lymphedema: a systematic review of the contemporary literature. J Cancer Surviv 5(4):320–336. doi:10.1007/s11764-011-0203-9

    Article  Google Scholar 

  • Lacomba MT, Sanchez MJY, Goni AZ, Merino DP, Del Moral OM, Tellez EC, Mogollon EM (2010) Effectiveness of early physiotherapy to prevent lymphoedema after surgery for breast cancer: randomised, single blinded, clinical trial. BMJ (Online) 340(7738):140. doi:10.1136/bmj.b5396

    Google Scholar 

  • Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174

    Article  Google Scholar 

  • Lee TS, Kilbreath SL, Sullivan G, Refshauge KM, Beith JM, Harris LM (2009) Factors that affect intention to avoid strenuous arm activity after breast cancer surgery. Oncol Nurs Forum 36(4):454–463. doi:10.1188/09.ONF.454-462

    Article  Google Scholar 

  • Lee TS, Kilbreath SL, Sullivan G, Refshauge KM, Beith JM (2010) Patient perceptions of arm care and exercise advice after breast cancer surgery. Oncol Nurs Forum 37(1):85–92. doi:10.1188/10.ONF.85-91

    Article  Google Scholar 

  • Lee MJ, Boland RA, Czerniec S, Kilbreath SL (2011) Reliability and concurrent validity of the perometer for measuring hand volume in women with and without lymphedema. Lymphat Res Biol 9(1):13–18. doi:10.1089/lrb.2010.0021

    Article  Google Scholar 

  • Lymphoedema Framework (2006) International consensus: best practice for the management of lymphoedema. MEP Ltd, London

    Google Scholar 

  • Miller LT (1998) Self-care approaches. Exercise in the management of breast cancer-related lymphedema. Innovat Breast Cancer Care 3(4):101–109

    Google Scholar 

  • National Institute for Health and Clinical Excellence (2014) Advanced breast cancer (update): diagnosis and treatment. NICE Clinical Guideline 81. http://www.nice.org.uk/guidance/cg81/chapter/1-Recommendations#managing-complications-2. Accessed 30 Nov 2015

  • Nielsen I, Gordon S, Selby A (2008) Breast cancer-related lymphoedema risk reduction advice: a challenge for health professionals. Cancer Treat Rev 34(7):621–628. doi:10.1016/j.ctrv.2007.11.002

    Article  Google Scholar 

  • Norman SA, Miller LT, Erikson HB, Norman MF, McCorkle R (2001) Development and validation of a telephone questionnaire to characterize lymphedema in women treated for breast cancer. Phys Ther 81(6):1192–1205

    Google Scholar 

  • O’Toole J, Jammallo LS, Miller CL, Skolny MN, Specht MC, Taghian AG (2013) Screening for breast cancer-related lymphedema: the need for standardization. Oncologist 18(4):350–352. doi:10.1634/theoncologist.2012-0387

    Article  Google Scholar 

  • Paskett ED, Dean JA, Oliveri JM, Harrop JP (2012) Cancer-related lymphedema risk factors, diagnosis, treatment, and impact: a review. J Clin Oncol 30(30):3726–3734. doi:10.1200/JCO.2012.41.8574

    Article  Google Scholar 

  • Perdomo M, Davies C, Levenhagen K, Ryans K (2014) Assessment measures of secondary lymphedema in breast cancer survivors. Rehabili Oncol 32(1):22–36

    Google Scholar 

  • Querci della Rovere G, Ahmad I, Singh P, Ashley S, Daniels IR, Mortimer P (2003) An audit of the incidence of arm lymphoedema after prophylactic level I/II axillary dissection without division of the pectoralis minor muscle. Ann R Coll Surg Engl 85(3):158–161

    Article  Google Scholar 

  • Radina M (2009) Breast cancer-related lymphedema: implications for family leisure participation. Family Relat Interdiscip J Appl Family Stud 58(4):445–459. doi:10.1111/j.1741-3729.2009.00565.x

    Article  Google Scholar 

  • Schmitz KH, Ahmed RL, Troxel A, Cheville A, Smith R, Lewis-Grant L, Bryan CJ, Williams-Smith CT, Greene QP (2009) Weight lifting in women with breast-cancer-related lymphedema. N Engl J Med 361(7):664–674. doi:10.1056/NEJMoa0810118

    Article  Google Scholar 

  • Schmitz KH, Ahmed RL, Troxel AB, Cheville A, Lewis-Grant L, Smith R, Bryan CJ, Williams-Smith CT, Chittams J (2010) Weight lifting for women at risk for breast cancer-related lymphedema: a randomized trial. JAMA J Am Med Assoc 304(24):2699–2706. doi:10.1001/jama.2010.1837

    Article  Google Scholar 

  • Shih YC, Xu Y, Cormier JN, Giordano S, Ridner SH, Buchholz TA, Perkins GH, Elting LS (2009) Incidence, treatment costs, and complications of lymphedema after breast cancer among women of working age: a 2-year follow-up study. J Clin Oncol 27(12):2007–2015. doi:10.1200/JCO.2008.18.3517

    Article  Google Scholar 

  • Sisman H, Sahin B, Duman BB, Tanriverdi G (2012) Nurse-assisted education and exercise decrease the prevalence and morbidity of lymphedema following breast cancer surgery. J BUON 17(3):565–569

    Google Scholar 

  • Stanton A, Modi A, Mellor R, Levick R, Mortimer P (2006) Diagnosing breast cancer-related lymphoedema in the arm. J Lymphoedema 1(1):12–15

    Google Scholar 

  • Stuiver MM, ten Tusscher MR, Agasi-Idenburg CS, Lucas C, Aaronson NK, Bossuyt PM (2015) Conservative interventions for preventing clinically detectable upper-limb lymphoedema in patients who are at risk of developing lymphoedema after breast cancer therapy. Cochrane Database Syst Rev 2:CD009765. doi:10.1002/14651858.CD009765.pub2

    Google Scholar 

  • Valentine RE, Lewis JS (2006) Intraobserver reliability of 4 physiologic movements of the shoulder in subjects with and without symptoms. Arch Phys Med Rehabil 87(9):1242–1249. doi:10.1016/j.apmr.2006.05.008

    Article  Google Scholar 

  • Vassard D, Olsen MH, Zinckernagel L, Vibe-Petersen J, Dalton SO, Johansen C (2010) Psychological consequences of lymphoedema associated with breast cancer: a prospective cohort study. Eur J Cancer 46(18):3211–3219. doi:10.1016/j.ejca.2010.07.041

    Article  Google Scholar 

  • Ward LC, Kilbreath SL, Dylke E (2015) Letter to the Editor Re: Bundred et al. “Comparison of multi-frequency bioimpedance with perometry for the early detection and intervention of lymphoedema after axillary node clearance for breast cancer”. Breast Cancer Research and Treatment 152 (1):227–228. doi:10.1007/s10549-015-3404-5

Download references

Authors’ contributions

EJ conceived and participated in the design of the study, carried out the data collection and clinical assessments, performed the statistical analysis, contributed to the interpretation of the data, drafted and revised the manuscript. AP participated in the design of the study, contributed to the interpretation of data, and helped draft and revise the manuscript. Both authors read and approved the final manuscript.

Acknowledgements

The research was funded by Professor A. Purushotham’s King’s College London Research Fund, sponsored by Guy’s and St Thomas’ NHS Foundation Trust, and supported by the Haven (London).

Competing interests

Eunice Jeffs was also employed by Guy’s and St Thomas’ NHS Foundation Trust as Macmillan Lymphoedema Specialist Practitioner at the time of conducting this study.

The authors have full control of all primary data and agree to allow the journal to review the data if requested.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to E. Jeffs.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jeffs, E., Purushotham, A. The prevalence of lymphoedema in women who attended an information and exercise class to reduce the risk of breast cancer-related upper limb lymphoedema. SpringerPlus 5, 21 (2016). https://doi.org/10.1186/s40064-015-1629-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s40064-015-1629-8

Keywords