Fig. 6From: MAP3K1-targeting therapeutic artificial miRNA suppresses the growth and invasion of breast cancer in vivo and in vitroOverexpression of Map3k1 amiRNA attenuated the in vivo tumor formation of 4T1 breast cancer cells. A Representative images of tumor formation in control-amiRNA and Map3k1 amiRNA-overexpressing cells in nude mice. B The growth curve of control-amiRNA and Map3k1 amiRNA-overexpressing tumors (*p < 0.05). C HE staining of control-amiRNA and Map3k1 amiRNA-overexpressing tumors indicated that control tumors displayed necrotic-like structure, invasion into muscle and fat tissues, whereas similar phenomena were not identified in Map3k1 amiRNA-overexpressing tumors (a, arrowheads indicated necrotic-like region; b, arrowhead indicated tumor invasion into muscle tissues; c, arrowhead tumor invasion into fat tissues)Back to article page