| All patients (n = 318) | lymph nodes removed ≤15 (n = 172) | lymph nodes removed > 15 (n = 146) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
 | Univariate cox regression analysis | Multivariate cox regression analysis | Multivariate analysis cox regression analysis | Multivariate analysis cox regression analysis | ||||||
Factor | RR (95% CI) | P | RR (95% CI) | P | No. | RR (95% CI) | P | No. | RR (95% CI) | P |
LNR | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
≤0.20 | 1.00 |  | 1.00 |  | 92 | 1.00 |  | 93 | 1 |  |
>0.2–0.65 | 2.91 (1.90–4.47) | <.001 | 2.20 (1.09–4.41) | 0.027 | 59 | 1.94 (0.91–4.12) | 0.085 | 38 | 1.05 (0.20–5.54) | 0.957 |
>0.65 | 4.31 (2.56–7.25) | <.001 | 3.07 (1.21–7.80) | 0.018 | 21 | 2.03 (0.56–7.33) | 0.282 | 18 | 2.64 (0.39–18.04) | 0.322 |
pN stage | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
pN1 (1–3) | 1.00 |  | 1.00 |  | 118 | 1.00 |  | 88 | 1 |  |
pN2 (4–9) | 2.52 (1.62–3.91) | <.001 | 1.28 (0.63–2.60) | 0.500 | 44 | 1.15 (0.51–2.60) | 0.745 | 30 | 4.31 (0.88–21.20) | 0.073 |
pN3 (≥10) | 3.85 (2.38–6.21) | <.001 | 1.31 (0.56–3.08) | 0.533 | 10 | 1.03 (0.23–4.64) | 0.970 | 31 | 5.03 (0.86–29.45) | 0.073 |
Age at diagnosis | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
<40 | 1.68 (0.99–2.86) | 0.056 | 1.82 (1.03–3.22) | 0.038 | 15 | 1.49 (0.61–3.66) | 0.384 | 18 | 3.43 (1.53–7.69) | 0.003 |
≥40 | 1.00 |  | 1.00 |  | 157 | 1.00 |  | 131 | 1.00 |  |
Tumour size, mm | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1–20 | 1.00 |  | 1.00 |  | 83 | 1.00 |  | 72 | 1.00 |  |
>20 | 2.25 (1.51–3.37) | <.001 | 1.52 (0.99–2.35) | 0.058 | 89 | 1.95 (1.08–3.51) | 0.027 | 77 | 0.76 (0.35–1.64) | 0.487 |
Histological grade | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1 | 1.00 | Â | 1.00 | Â | 22 | 1.00 | Â | 20 | 1.00 | Â |
2 | 2.16 (0.97–4.83) | 0.060 | 1.84 (0.81–4.18) | 0.143 | 58 | 2.18 (0.63–7.60) | 0.221 | 62 | 1.79 (0.57–5.60) | 0.318 |
3 | 3.21 (1.46–7.05) | 0.004 | 2.21 (0.98–4.95) | 0.055 | 77 | 3.73 (1.13–12.32) | 0.031 | 53 | 1.40 (0.42–4.60) | 0.584 |
Unknown | 1.35 (0.45–4.02) | 0.590 | 1.03 (0.34–3.11) | 0.958 | 15 | 1.51 (0.30–7.60) | 0.619 | 14 | 0.73 (0.15–3.69) | 0.706 |
ER | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Negative | 1.00 | Â | 1.00 | Â | 11 | 1.00 | Â | 13 | 1.00 | Â |
Positive | 0.37 (0.18–0.77) | 0.008 | 0.49 (0.23–1.06) | 0.071 | 36 | 0.59 (0.19–1.87) | 0.367 | 35 | 0.20 (0.06–0.65) | 0.007 |
Unknown | 0.59 (0.32–1.09) | 0.091 | 0.60 (0.32–1.13) | 0.115 | 125 | 0.76 (0.29–1.95) | 0.562 | 101 | 0.26 (0.10–0.66) | 0.005 |
Chemotherapy | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
No | 1.00 | Â | 1.00 | Â | 96 | 1.00 | Â | 61 | 1.00 | Â |
Yes | 1.58 (1.05–2.37) | 0.028 | 1.04 (0.67–1.61) | 0.860 | 76 | 1.24 (0.69–2.22) | 0.480 | 85 | 0.61 (0.29–1.30) | 0.202 |