Table 2 Meta-analysis of the R72P polymorphism of the gene TP53 on breast cancer, by pooling data per continent
From: Association of the TP53 codon 72 polymorphism and breast cancer risk: a meta-analysis
RR vs. RP | RR vs. PP | RP vs. PP | RR+RP vs. PP | RR vs. RP+PP | |
|---|---|---|---|---|---|
OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
Africa | 1.41 (0.90-2.22) | 1.30 (0.69-2.44) | 0.99 (0.54-1.83) | 1.05 (0.6-1.86) | 1.32 (0.86-2.01) |
America | 1.04 (0.87-1.23) | 1.04 (0.82-1.33) | 1.01 (0.88-1.16) | 0.98 (0.86-1.11) | 0.96 (0.90-1.03) |
Asia | 1.05 (0.88-1.26) | 1.24 (0.87-1.78) | 1.15 (0.85-1.57) | *1.23 (1.07-1.41) | 1.04 (0.93-1.17) |
Europe | 1.09 (0.97-1.22) | 1.10 (0.93-1.31) | 1.01 (0.92-1.11) | 1.04 (0.95-1.13) | 1.03 (0.98-1.08) |
Overall | 1.01 (0.97-1.04) | 1.05 (0.99-1.12) | 1.05 (0.99-1.12) | 1.06 (0.99-1.12) | 1.05 (0.98-1.05) |
Heterogeneity | χ2 = 3.91 | χ2 = 5.42 | χ2 = 5.78 | χ2 = 6.15 | χ2 = 4.53 |
P = 0.27 | P = 0.14 | P = 0.12 | P = 0.10 | P = 0.21 |