Gastrointestinal perforation due to vasculitis at primary diagnosis of eosinophilic granulomatosis with polyangiitis (EGPA) despite a high dose glucocorticosteroids treatment

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Table 1 Eosinophilic granulomatosis with polyangiitis patients’ characteristics (case 1, 2)

Characteristics		Patient 1	Patient 2
Time of diagnosis		4/2010	1/2009
Dosage of prednisolone ^a		80 mg	90 mg
Days of GC treatment ^b		7	10
Manifestations of EGPA
	Heart failure (NYHA stage)	II	II
	Myocarditis ^c	Present	Present
	Neuropathy	Mononeuritis multiplex L1	Polyneuropathy
	Lung	Bronchial asthma	Asthma bronchiale
		Eosophile infiltration
	Kidney	Mild proteinuria (0.5 g/24 h)	Glomerular hematuria
	Eosinophilic granulocytes ^d	5500/μl	4900/μl
IgE value		Elevated	Elevated
pANCA value	(Positive) ^e	12.8 U/ml^f	14.1 U/ml^f

^aintraveneous application once a day; ^bGC = glucocorticosteroides, till perforation followed by abdominal surgery; EGPA = eosinophilic granulomatosis with polyangiitis; ^chistological proved by myocardial biopsy; ^dcounted in periphereal blood; ^epANCA = perinuclear pattern of antineutrophilic cytoplasmatic autoantibodies, tested by immunofluorescence test and by ELISA for myeloperoxidase autoantibodies (anti-MPO) ^fin U/ml; NYHA = New York Heart Association classification of heart failure.