Table 6 Incidence of IORN of the upper and lower jaw in the literature

Ben-David et al. 2007 (n = 176)

0

Multiple tumour localizations

Primary treatment (no surgery)

IMRT

108/176 radiochemotherapy

Berger and Bensadoun 2010

1-5%

Literature survey

Crombie et al. 2012 (n = 54)

36%

53/54 radiochemotherapy

Gomez et al. 2011 (n = 168)

1.2%

Multiple tumour localizations

IMRT

Gomez et al. 2009 (n = 35)

5%

IMRT

Jereczek-Fossa and Orecchia 2002

0.4-56%

Literature survey

Jham et al. 2008 (n = 207)

5.5%

Head and neck cancer

Katsura et al. 2008 (n = 39)

15%

Lee et al. 2008 (n = 189)

6.6%

Oral cavity and oropharynx

Monnier et al. 2011 (n = 73)

40%

Oral cavity and oropharynx

Oh et al. 2004 (n = 81)

4.9%

Reuther et al. 2003 (n = 830)

8.2%

Oral cavity and oropharynx

Stenson et al. 2010 (n = 27)

18.4%

Surgery, adjuvant radiochemotherapy

Storey et al. 2001 (n = 83)

6%

Malignant submandibular tumours

Studer et al. 2011 (n = 304)

Grade 2 EORTC: 1.6%

Oral cavity and oropharynx

Conventional dental care vs. risk-adapted dental care

IMRT

Thiel 1989

4-35%

Literature survey

Thorn et al. 2000 (n = 80)

74%/3 years

Multiple tumour localizations

Tsai et al. 2012 (n = 402)

7.5%

Oropharyngeal cancer, median time to IORN 8 months

Turner et al. 1996 (n = 333)

5.9%