Table 4 Intermolecular interaction energies of Bortezomib (Velcade®) inhibitor in the catalytic subunits of the crystal structure of yeast 20S proteasome and in the equivalent subunits of the Pf 20S proteasome model
Catalytic subunits | Intermolecular Energy (kcal/mol) |
|---|---|
2F16_Beta1 | -6.45 |
2F16_Beta2 | -6.60 |
2F16_Beta5 | -6.84 |
Pf_Beta1 | -5.84 |
Pf_Beta2 | -1.54 |
Pf_Beta5 | -4.29 |