Comparison of BEAM vs. LEAM regimen in autologous transplant for lymphoma at AIIMS

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Table 1 Patient characteristic pre-transplant

High dose chemotherapy regimen
	BEAM (n = 34)		LEAM (n= 17)
	N	%	N	%	p
Median age (range)	37 (17 – 63)		26 (18–59)		0.070
Sex					0.472
Male	28	82	12	71
Female	6	18	5	29
Diagnosis					0.771
NHL	18	53	8	47
HL	16	47	9	53
Number of prior chemotherapy lines					0.638
1	3	9	3	18
2	14	41	7	41
≥ 3	17	50	7	41
Median time Dx to transplant (months)	24.3 (1.9 – 128.7)		17.3 (2.0 – 144.1)		0.187
Pre transplant disease status					0.074
CR	13	38	5	30
PR	18	53	6	35
Progressive/ refractory disease	3	9	6	35
Chemosensitivity					0.045
Chemosensitive disease	31	91	11	65
Chemorefractory disease	3	9	6	35
ECOG PS					0.650
0 – 1	28	85	16	94
≥ 2	5	15	1	6
HCT-CI					0.019
Low risk (0)	19	56	8	47
Intermediate risk (1 – 2)	15	44	5	29
High risk (≥ 3)	0	-	4	24
Median CD34 cell dose	2.3 x 10⁶/kg		2.4 x 10⁶/kg		0.536

Abbreviations: NHL, Non Hodgkin’s lymphoma; HL, Hodgkin’s lymphoma; Dx, Diagnosis; CR, Complete remission; PR, Partial remission; ECOG PS, Eastern Cooperative Oncology Group Performance Status; HCT-CI, Hematopoietic Cell Transplant Co morbidity Index.