Table 3 Association of HLA, CTLA, FAS, and TNF loci with severe fibrosis and normalisation of ALT in type 1 AIH patients
SNP |  |  | Genotype |  |  | MAF | Unadjusted±P value (allele) | OR (allele) [95% CI] |
|---|---|---|---|---|---|---|---|---|
rs2187668 (HLA-DRB1*03:01) | Â | Â | AA | AG | GG | A | ||
|  | Fibrosis ≥ Metavir 3 | Yes | 4(0.089) | 16(0.356) | 25(0.556) | 24(0.267) | 0.46 | 0.76 [0.38-1.55] |
| Â | (at diagnosis) | No | 5(0.161) | 10(0.323) | 16(0.516) | 20(0.323) | Â | Â |
| Â | Incomplete normalization of ALT | Yes | 1(0.067) | 6(0.400) | 8(0.533) | 8(0.267) | 0.67 | 0.82 [0.34-2.01] |
| Â | (at 6Â months post diagnosis) | No | 9(0.145) | 20(0.323) | 33(0.532) | 38(0.306) | Â | Â |
rs660895 (HLA-DRB1*04:01) | Â | Â | AA | AG | GG | G | Â | Â |
|  | Fibrosis ≥ Metavir 3 | Yes | 27(0.600) | 15(0.333) | 3(0.067) | 21(0.233) | 0.22 | 1.56 [0.76-3.22] |
| Â | (at diagnosis) | No | 13(0.419) | 16(0.516) | 2(0.065) | 20(0.323) | Â | Â |
| Â | Incomplete normalization of ALT | Yes | 9(0.600) | 4(0.267) | 2(0.133) | 8(0.267) | 0.96 | 1.00 [0.40-2.46] |
| Â | (at 6Â months post diagnosis) | No | 32(0.516) | 27(0.435) | 3(0.048) | 33(0.266) | Â | Â |
rs3749971 (HLA-A1-B8-DR3) | Â | Â | AA | AG | GG | A | Â | Â |
|  | Fibrosis ≥ Metavir 3 | Yes | 3(0.067) | 13(0.289) | 29(0.644) | 19(0.211) | 0.26 | 1.24 [0.54-2.83] |
| Â | (at diagnosis) | No | 1(0.032) | 9(0.290) | 21(0.677) | 11(0.177) | Â | Â |
| Â | Incomplete normalization of ALT | Yes | 0(0.000) | 6(0.400) | 9(0.600) | 6(0.200) | 0.98 | 0.99[0.37-2.68] |
| Â | (at 6Â months post diagnosis) | No | 4(0.065) | 17(0.274) | 41(0.661) | 25(0.202) | Â | Â |
rs231775 (CTLA4) | Â | Â | AA | AG | GG | G | Â | Â |
|  | Fibrosis ≥ Metavir 3 | Yes | 20(0.444) | 15(0.333) | 10(0.222) | 35(0.389) | 0.29 | 0.69 [0.35-1.38] |
| Â | (at diagnosis) | No | 13(0.419) | 17(0.548) | 1(0.032) | 19(0.306) | Â | Â |
| Â | Incomplete normalization of ALT | Yes | 7(0.467) | 6(0.400) | 2(0.133) | 10(0.333) | 0.70 | 1.18 [0.51-2.74] |
| Â | (at 6Â months post diagnosis) | No | 26(0.419) | 26(0.419) | 10(0.161) | 46(0.371) | Â | Â |
rs1800629 (TNF) | Â | Â | AA | AG | GG | A | Â | Â |
|  | Fibrosis ≥ Metavir 3 | Yes | 5(0.111) | 19(0.422) | 21(0.467) | 29(0.322) | 0.68 | 1.16 [0.57-2.35] |
| Â | (at diagnosis) | No | 4(0.129) | 10(0.323) | 17(0.548) | 18(0.290) | Â | Â |
| Â | Incomplete normalization of ALT | Yes | 1(0.067) | 7(0.467) | 7(0.467) | 9(0.300) | 0.81 | 0.90 [0.38-2.14] |
| Â | (at 6Â months post diagnosis) | No | 9(0.145) | 22(0.355) | 31(0.500) | 40(0.323) | Â | Â |
rs1800682 (FAS) | Â | Â | CC | CT | TT | C | Â | Â |
|  | Fibrosis ≥ Metavir 3 | Yes | 14(0.311) | 21(0.467) | 10(0.222) | 49(0.544) | 0.035 | 2.03 [1.05-3.93] |
| Â | (at diagnosis) | No | 5(0.161) | 13(0.419) | 13(0.419) | 23(0.371) | Â | Â |
|  | Incomplete normalization of ALT | Yes | 9(0.600) | 4(0.267) | 2(0.133) | 22(0.733) | 0.0015± | 3.94 [1.62-9.54] |
| Â | (at 6Â months post diagnosis) | No | 10(0.161) | 31(0.500) | 21(0.339) | 51(0.411) | Â | Â |