Marker | Description | Expression on stem cell-like populations | References |
---|---|---|---|
H type 1 | SSEA-5, stage-specific embryonic antigen-5; carried on proteins Fucα1-2Galβ1-3GlcNAcβ1- | PSC, iPSC; CSC (germ cell carcinomas) | 1 |
CD15 | Lewis X, SSEA-1, stage-specific embryonic antigen-1; carried on lipids or proteins Galβ1-4[Fucα1-3]GlcNAcβ1-3Galβ1- | ESC, NSC, MSC; CSC (globlastomas) | 2-7 |
CD60a | GD3; ganglioside NeuAcα2-8NeuAcα2-3Galβ1-4Glcβ1- | NSC; CSC (differentiated germ cell carcinomas, melanomas) | 7, 8 |
CD77 | Gb3, Pk antigen, Burkitt lymphoma antigen (BLA); globoside Galα1-4Galβ1-4Glcβ1- | CSC (Burkitt lymphoma, breast cancer, germ cell carcinomas) | 8, 9 |
CD173 | H type 2; carried on proteins or lipids Fucα1-2Galβ1-4GlcNAcβ1- | ESC cell lines, HProgC, MSC | 9-11, 13 |
CD174 | Lewis Y; carried on proteins or lipids Fucα1-2Galβ1-4[Fucα1-3]GlcNAcβ1- | HProgC; CSC (breast cancer) | 9, 11 |
CD175 | Tn antigen; carried on proteins GalNAcα1- | ESC cell lines; onfFN | 12,13 |
CD176 | TF, Thomsen-Friedenreich antigen, core-1; carried on proteins Galβ1-3GalNAcα1- | ESC; CSC (diverse carcinomas and leukemias); onfFN | 12-14 |
GD2 | OFA-I-2; ganglioside GalNAcβ1-4[NeuAcα2-8NeuAcα2-3]Galβ1-4Glcβ1- | NSC, MSC; CSC (differentiated germ cell carcinomas, breast cancer, melanomas) | 7, 8, 10, 15 |
Gb4 | Globoside GalNAcβ1-3Galα1-4Galβ1-4Glcβ1- | CSC (germ cell carcinomas) | 8 |
Gb5 | SSEA-3, stage-specific embryonic antigen-3; globoside Carries TFβ (the β-anomer of TF) Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glcβ1- | ESC, MSC, iPSC; CSC (breast cancer, germ cell carcinomas) | 4, 8, 16-19 |
Sialyl-Gb5 | SSEA-4, stage-specific embryonic antigen-4, GL7; globoside NeuAcα2-3Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glcβ1- | ESC, MSC, iPSC, ProgC (breast); CSC (germ cell carcinomas) | 4, 8, 16, 17, 19-21 |
Globo-H | Carried on proteins or lipids Fucα1-2Galβ1-3GalNAcβ1-3Galα1-4Gal- | CSC (breast cancer) | 18 |
TRA-1-60 | Tumor-recognition antigen; carried on protein Sialylated keratan sulfate proteoglycan | ESC, MSC; CSC (teratocarcinomas) | 4, 19, 22 |