Marker | Description | Expressed on | Selected references | |
---|---|---|---|---|
Cellular localization | Normal stem or progenitor cells | Cancer stem cells | ||
ALDH1 | Aldehyde dehydrogenase Cytoplasma | AdSC (breast) | CSC (breast and other carcinomas | 1 |
Bmi-1 | Polycomb protein Cytoplasma | HSC, NSC, AdSC (intestine, breast, prostate) | CSC (breast, prostate cancer, neuroblastomas, leukemias) | 2, 3 |
CD29 | Integrin-β1 Membrane | AdSC (breast) | CSC (breast, colon cancer) | 4, 5 |
CD34 | Adhesion protein Membrane | HSC, MSC, HProgC, EnProgC | CSC (leukemias, sarcomas) | 6-11 |
CD44 | Hyaluronan receptor, adhesion protein Membrane | HSC, HProgC, PSC | CSC (many carcinomas) | 12-16 |
CD90 | Thy-1 Membrane | ProgC (thymus), MSC | CSC (breast cancer, glioblastomas) | 17, 18 |
CD117 | SCF receptor Membrane | ProgC | CSC (breast, ovarian, lung cancer, glioblastomas) | 16, 19 |
CD133 | Prominin-1 Membrane | HSC, NSC, AdSC (colon) | CSC (many carcinomas, glioblastomas, melanomas) | 20-24 |
CDw338 | ABCG2, Bcrp1 ABC transporter, permitting multi-drug resistance Membrane | ESC, HSC, AdSC | CSC (breast, lung cancer, glioblastomas, melanomas) | 25, 26 |
Nestin | Class VI intermediate filament protein Cytoplasma | NSC, ProgC (brain), HProgC | CSC (glioblastomas, melanomas) | 27, 28 |
Oct-4 | Transcription factor Cytoplasma | ESC, iPSC | CSC (many carcinomas) | 29, 30 |