Table 1 Effect of various molecules on growth, viability and ergosterol biosynthesis in C. albicans
From: Small molecules inhibit growth, viability and ergosterol biosynthesis in Candida albicans
Group | Molecules | MIC (mg/ml) | MFC (mg/ml) | % decrease in ergosterol content of C. albicans at their respective MIC value |
|---|---|---|---|---|
Most effective (0.0625-0.5 mg/ml) | cinnamaldehyde | 0.0625 | 0.25 | 58 (± 0.502) |
piperidine | 0.25 | 1 | 60 (± 0.123) | |
indole | 0.5 | 1 | 55 (± 0.652) | |
furfuraldehyde | 0.5 | 1 | 96 (± 0.926) | |
citral | 0.5 | 1 | 99 (± 0.865) | |
Moderately effective (1–2 mg/ml) | beta-Pinene | 1 | 1 | 90 (± 0.325) |
salicylic acid | 1 | NA | NE | |
guaiacol | 2 | 2 | NE | |
cymene | 2 | 8 | NE | |
Less effective (4–8 mg/ml) | caffeine | 4 | NA | NE |
camphene | 4 | 4 | NE | |
citronellol | 4 | 8 | NE | |
geraniol | 4 | NA | NE | |
geranyl acetate | 4 | NA | NE | |
alpha-Pinene | 8 | NA | 40 | |
carvone | 8 | NA | NE | |
linalool | 8 | NA | NE | |
thujone | 8 | NA | NE | |
Non effective | bisabolol | NA | NA | NE |
jasmonate | NA | NA | NE | |
isopulegol | NA | NA | NE | |
limonene | NA | NA | NE | |
1,4-cineole | NA | NA | NE | |
1,8-cineole | NA | NA | NE | |
menthol | NA | NA | NE |