Effects of rocuronium and vecuronium on initial rundown of endplate potentials in the isolated phrenic nerve diaphragm preparation of rats

SpringerPlus

Table 3 Changes in string initial rundown rates of endplate potentials (EPPs) before and after treatment of the isolated rat phrenic nerve diaphragm preparation with rocuronium or vecuronium

Drug (μg/ml)	Before treatment			3 min after treatment			5 min after treatment
Drug (μg/ml)	M1	MX	R (%)	M1	MX	R (%)	M1	MX	R (%)
Rocuronium 2.5	46 ± 11	34 ± 10	26	46 ± 10	28 ± 10	40*	45 ± 12	26 ± 10*	42*
Vecuronium 0.5	46 ± 11	33 ± 11	28	46 ± 11	31 ± 10	33	45 ± 12	29 ± 11*	37*

^* P < 0.05, compared with the corresponding group without drug treatment; n = 5. M1, the first quantum content of EPP; MX, the 11 to 55 average quantum content of EPP; R, the rundown rate. M = Vc/q; Vc is the corrected amplitude of EPP and q is the quantum size of the MEPP. Data shown are means ± SEM.