Effects of rocuronium and vecuronium on initial rundown of endplate potentials in the isolated phrenic nerve diaphragm preparation of rats

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Table 1 Effects of rocuronium on the amplitude of endplate potentials (EPPs) in the isolated rat phrenic nerve diaphragm preparation at different time points after treatment

Rocuronium (μg/ml)	EPP (mV) before treatment	EPP (mV) at different times after treatment
Rocuronium (μg/ml)	EPP (mV) before treatment	1 min	3 min	5 min
Control	32.4 ± 3.3	32.2 ± 3.4	32.2 ± 3.3	31.4 ± 3.5
2.5	32.6 ± 3.6	32.3 ± 3.4	32.1 ± 3.5	31.2 ± 3.3
5.0	33.5 ± 3.4	32.4 ± 3.3	22.4 ± 2.9^*#	14.6 ± 2.1^**##
10.0	34.8 ± 4.3	27.2 ± 2.5^**	16.4 ± 1.3^**##	12.4 ± 1.3^**##
20.0	33.2 ± 3.1	22.4 ± 2.3^*#	12.4 ± 2.3^*#	9.4 ± 1.1^**##

^* P < 0.05, ^** P < 0.01, compared with the corresponding group without rocuronium; ^# P < 0.05, ^## P < 0.01, compared with the control at the same time point; n = 5. Data shown are means ± SEM.