Integrin triplets of marine sponges in the murine and human MHCI-CD8 interface and in the interface of human neural receptor heteromers and subunits

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Table 2 Example of integrin triplets of marine sponges in murine and human proteins

Protein	Species	Type	LLG	GLL	ITL	RPA	GDR	RDG	DGR
ITGA	Sponge	Integrin-α	-	-	+	+	+	-	-
ITGB	Sponge	Integrin-β	+	+	-	-	-	-	-
ITGB4	Sponge	Integrin-β	-	-	-	-	-	+	+
MHC Class I	Mouse	Immune receptor	+	-	+	+	-	-	+
CD8a	Mouse	Immune receptor	+	-	+	-	-	-	-
CD8b	Mouse	Immune receptor	-	-	-	-	-	-	-
MHC Class I	Human	Immune receptor	+	-	+	+	-	+	+
CD8a	Human	Immune receptor	-	-	+	+	-	-	-
CD8b	Human	Immune receptor	-	+	+	-	-	-	-
CXCR4	Human	Immune receptor	-	-	+	-	-	-	-
TSHR	Human	Endocrine receptor	-	-	-	+	-	-	-
FGFR1	Human	Receptor tyrosine kinase	-	-	-	+	-	-	-
5HT1A	Human	Neural receptor	+	-	-	-	-	-	-
Collagen	Human	Matrix protein	-	-	-	-	+	+	+
ITGAIIB	Human	Integrin-α	+	+	-	-	-	+	+
ITGAL	Human	Integrin-α	-	+	-	-	-	-	-
ITGAM	Human	Integrin-α	+	+	-	-	-	-	-
ITGAV	Human	Integrin-α	+	+	-	-	-	-	-
ITGAX	Human	Integrin-α	+	+	+	-	+		-
ITGB2	Human	Integrin-β	-	+	-	-	-	-	+
ITGB3	Human	Integrin-β	-	+	-	-	-	-	+
ITGB4	Human	Integrin-β	+	-	-	-	-	-	-
ITGB5	Human	Integrin-β	+	-	-	-	-	+	-
ITGB6	Human	Integrin-β	-	+	-	-	-	-	-
ITGB8	Human	Integrin-β	-	+	-	-	+	-	-
ACHA	Human	Neural receptor subunit	+	-	-	-	-	-	-
ACHB	Human	Neural receptor subunit	+	-	+	+	+	-	-
ACHD	Human	Neural receptor subunit	-	+	+	+	-	-	-
ACHE	Human	Neural receptor subunit	+	+	-	-	-	-	-
GABAB1	Human	Neural receptor	+	+	+	-	-	-	-
GABAB2	Human	Neural receptor	-	+	+	-	-	-	-
mGluR1	Human	Neural receptor	-	+	+	-	-	-	-