Novel variations in the adiponectin gene (ADIPOQ) may affect distribution of oligomeric complexes

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Table 1 Demographic Characteristics of Individuals with Variations (SNV) and Matched Controls

SNV	Subject^a	Age	Sex	Race	Puberty	BMI (kg/m²)	BMI Z	Insulin (pmol/l)
MIS	Index	14.7	M	W	Post	21.7	0.67	25.6
	Match – A	14.9	M	W	Post	21.4	0.54	44.0
	Match - B	15.1	M	W	Post	22.3	0.74	133.7
P32L	Index	12.8	F	W	Peri	23.1	1.19	330.9*
	Match - A	12.6	F	W	Peri	22.9	1.19	202.7*
	Match - B	13.0	F	W	Peri	22.3	0.99	112.9
R55C	Index	13.4	M	B	Peri	33.3	2.38	350.2*
	Match - A	13.7	M	B	Peri	35.9	2.51	330.6*
	Match - B	13.7	M	B	Peri	29.1	2.04	84.9
Y111H	Index	11.8	F	W	Peri	18.3	0.14	74.0
	Match - A	12.0	F	W	Peri	18.5	0.17	77.8
	Match - B	12.1	F	W	Peri	18.7	0.20	25.3
5th - 95th Percentiles^b		10.8 – 17.9				16.5 – 34.6	−1.02 – 2.35	35.0 – 348.2

* Insulin resistant.
^a “Index” refers to the individual carrying the variation noted. Both Match - A and Match - B subjects were sequenced to verify that they did not harbor non synonymous SNVs in ADIPOQ. Match- A refers to the individual selected to match the Index individual by age, sex, race, puberty status, BMI and insulin levels. Match – B refers to the individual selected to match the Index by age, sex, race, puberty status, and BMI, but to be as divergent on insulin levels. ^b Percentiles derived from the larger cohort of 2501 children.